Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MLYCD | O95822 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 7/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 7/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 6/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7909464 | 0.86 | CA1 (0.39) | ALDH1A1HCRTR2RECQLSMN1; SMN2 | |
| SCHEMBL2678169 | 0.86 | CA1 (0.39) | ALDH1A1HCRTR2RECQLSMN1; SMN2 | |
| SCHEMBL3381296 | 0.86 | CA1 (0.39) | ALDH1A1HCRTR2RECQLSMN1; SMN2 | |
| SCHEMBL4839197 | 0.86 | CA1 (0.39) | ALDH1A1HCRTR2RECQLSMN1; SMN2 | |
| SCHEMBL4033152 | 0.86 | CA1 (0.39) | ALDH1A1HCRTR2RECQLSMN1; SMN2 | |
| SCHEMBL5278729 | 0.84 | CA1 (0.37) | ALDH1A1HCRTR2 | |
| SCHEMBL5277573 | 0.82 | HCRTR2 (0.36) | ALDH1A1HCRTR2 | |
| SCHEMBL12789669 | 0.81 | HCRTR2 (0.36) | POLBHCRTR2 | |
| SCHEMBL5180906 | 0.77 | CA1 (0.37) | HCRTR2 | |
| SCHEMBL15116368 | 0.77 | MMP2 (0.37) | HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753758-B1 | MERCAPTOIMIDAZOLES AS CCR2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2009-03-11 | — | — | EP | disclosed |