Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 7/20 | 0.68 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.68 |
| ▸ | ABL1 | P00519 | 2/20 | 0.68 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.68 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | STAT6 | P42226 | 1/20 | 0.67 |
| ▸ | GALR3 | O60755 | 1/20 | 0.61 |
| ▸ | CASP1 | P29466 | 1/20 | 0.58 |
| ▸ | CASP7 | P55210 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13914788 | 0.93 | MAPT (0.63) | RETADORA1ABL1ALKADORA2A | |
| SCHEMBL13913731 | 0.92 | ALDH1A1 (0.62) | RETADORA1ABL1ALKADORA2A | |
| SCHEMBL13914783 | 0.92 | RET (0.67) | RETADORA1ABL1ALKADORA2A | |
| SCHEMBL13914789 | 0.90 | MAPT (0.60) | RETADORA1ABL1ALKADORA2A | |
| SCHEMBL13914785 | 0.89 | RET (0.68) | RETADORA1ABL1ALKADORA2A | |
| SCHEMBL13914805 | 0.89 | RET (0.68) | RETADORA1ABL1ALKADORA2A | |
| SCHEMBL13914793 | 0.89 | MAPT (0.59) | RETADORA1ABL1ALKADORA2A | |
| SCHEMBL13914825 | 0.89 | MAPT (0.61) | RETADORA1ABL1ALKADORA2A | |
| SCHEMBL13914806 | 0.88 | ALDH1A1 (0.68) | RETADORA1ABL1ALKADORA2A | |
| SCHEMBL13913723 | 0.88 | ALDH1A1 (0.71) | RETADORA1ABL1ALKADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |