Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 18/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.63 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26010418 | 0.88 | ADORA1 (0.79) | ADORA1KDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL26010522 | 0.88 | ADORA1 (0.78) | ADORA1KDM4EALDH1A1MAPTNPSR1 | |
| SCHEMBL13913771 | 0.87 | ADORA1 (1.00) | ADORA1KDM4EALDH1A1NPSR1MEN1 | |
| SCHEMBL4309701 | 0.85 | ADORA1 (1.00) | ADORA1KDM4EALDH1A1NPSR1ADORA2B | |
| SCHEMBL13913698 | 0.85 | ADORA1 (0.81) | ADORA1KDM4EMAPTNPSR1MEN1 | |
| SCHEMBL13913766 | 0.84 | ALDH1A1 (0.74) | ADORA1KDM4EALDH1A1MAPTNPSR1 | |
| SCHEMBL13913604 | 0.84 | ADORA1 (1.00) | ADORA1KDM4ENPSR1ADORA2BADORA3 | |
| SCHEMBL13913746 | 0.84 | ADORA1 (0.80) | ADORA1KDM4EALDH1A1MAPTNPSR1 | |
| SCHEMBL13913670 | 0.84 | ADORA1 (1.00) | ADORA1ALDH1A1MEN1KMT2AADORA2B | |
| SCHEMBL25361247 | 0.84 | ADORA1 (0.72) | ADORA1KDM4EALDH1A1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |