Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 17/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.55 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13914092 | 0.93 | ADORA1 (0.74) | ADORA1ADORA2B | |
| SCHEMBL13913903 | 0.87 | ADORA1 (0.64) | ADORA1KDM4EHTTNPSR1ADORA2B | |
| SCHEMBL13914097 | 0.87 | ADORA1 (0.54) | ADORA1KDM4EHTTNPSR1ADORA2B | |
| SCHEMBL13914105 | 0.86 | ADORA1 (0.70) | ADORA1KDM4EHTTNPSR1ADORA2B | |
| SCHEMBL13914095 | 0.83 | ADORA1 (0.55) | ADORA1KDM4EADORA2BSIRT1MEN1 | |
| SCHEMBL13914093 | 0.81 | ADORA1 (0.57) | ADORA1KDM4EHTTNPSR1ADORA2B | |
| SCHEMBL13913879 | 0.81 | ADORA1 (0.66) | ADORA1ADORA2BSIRT1 | |
| SCHEMBL13914094 | 0.81 | ALDH1A1 (0.80) | ADORA1KDM4EHTTNPSR1ADORA2B | |
| SCHEMBL13913863 | 0.80 | ADORA1 (0.66) | ADORA1KDM4ENPSR1MEN1USP2 | |
| SCHEMBL13913983 | 0.79 | ADORA1 (0.68) | ADORA1KDM4EHTTNPSR1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |