Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 7/20 | 0.71 |
| ▸ | ABL1 | P00519 | 2/20 | 0.71 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.71 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.65 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.65 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.61 |
| ▸ | PDE5A | O76074 | 1/20 | 0.60 |
| ▸ | PDE1A | P54750 | 1/20 | 0.60 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.60 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.60 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | CASP7 | P55210 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13913678 | 0.93 | RET (0.80) | RETABL1ALKADORA1ADORA2A | |
| SCHEMBL13914553 | 0.90 | RET (0.71) | RETABL1ALKADORA1ADORA2A | |
| SCHEMBL13914732 | 0.89 | RET (0.72) | RETABL1ALKADORA1ADORA2A | |
| SCHEMBL13914424 | 0.89 | RET (0.68) | RETABL1ALKADORA1ADORA2A | |
| SCHEMBL13914500 | 0.89 | RET (0.67) | RETABL1ALKADORA1ADORA2A | |
| SCHEMBL13914488 | 0.88 | RET (0.76) | RETABL1ALKADORA1ADORA2A | |
| SCHEMBL13913680 | 0.88 | PDE5A (0.73) | RETABL1ALKADORA1ADORA2A | |
| SCHEMBL13914518 | 0.88 | RET (0.78) | RETABL1ALKADORA1ADORA2A | |
| SCHEMBL13913708 | 0.87 | RET (0.74) | RETABL1ALKADORA1ADORA2A | |
| SCHEMBL13913530 | 0.87 | SIRT1 (0.76) | RETABL1ALKADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |