Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 9/20 | 0.79 |
| ▸ | NR3C1 | P04150 | 10/20 | 0.55 |
| ▸ | AR | P10275 | 7/20 | 0.55 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2168575 | 0.92 | PGR (0.69) | PGRNR3C1ARNR3C2CYP3A4 | |
| SCHEMBL15354859 | 0.92 | PGR (0.69) | PGRNR3C1ARNR3C2CYP3A4 | |
| SCHEMBL13918127 | 0.92 | PGR (0.69) | PGRNR3C1ARNR3C2CYP3A4 | |
| SCHEMBL2168200 | 0.92 | PGR (0.69) | PGRNR3C1ARNR3C2CYP3A4 | |
| SCHEMBL12473404 | 0.92 | PGR (0.69) | PGRNR3C1ARNR3C2CYP3A4 | |
| SCHEMBL2168665 | 0.91 | PGR (0.68) | PGRNR3C1ARNR3C2CYP3A4 | |
| SCHEMBL16479391 | 0.91 | PGR (0.68) | PGRNR3C1ARNR3C2CYP3A4 | |
| Promegestone SCHEMBL37770 | 0.88 | PGR (1.00) | PGRNR3C1ARNR3C2CYP3A4 | |
| SCHEMBL16016504 | 0.88 | PGR (0.67) | PGRNR3C1ARNR3C2CYP3A4 | |
| SCHEMBL13918110 | 0.88 | PGR (0.67) | PGRNR3C1ARNR3C2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2033965-A2 | 17-alpha-substituted-11-beta-substituted-4-aryl and 21-substituted 19-norpregnadienedione as antiprogestational agents | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services (US) | 2009-03-11 | — | — | EP | disclosed |