Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.66 |
| ▸ | PDE11A | Q9HCR9 | 10/20 | 0.66 |
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.66 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | PLD1 | Q13393 | 3/20 | 0.38 |
| ▸ | PLD2 | O14939 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13920539 | 0.85 | PDE4B (0.62) | PDE4BPDE11APDE10A | |
| SCHEMBL13918938 | 0.84 | PDE4B (0.81) | PDE4BPDE11APDE10A | |
| SCHEMBL8274209 | 0.82 | PDE4B (0.47) | PDE4BPDE11APDE10A | |
| SCHEMBL13918517 | 0.80 | PDE4B (1.00) | PDE4BPDE11APDE10A | |
| SCHEMBL8274207 | 0.77 | PDE4B (0.56) | PDE4BPDE11APDE10A | |
| SCHEMBL13920535 | 0.76 | PDE4B (0.49) | PDE4BPDE11APDE10A | |
| SCHEMBL13920541 | 0.76 | PDE4B (0.54) | PDE4BPDE11APDE10APDE3A | |
| SCHEMBL8274204 | 0.73 | PDE4B (0.47) | PDE4BPDE11APDE10APDE3A | |
| SCHEMBL13920533 | 0.70 | PDE4B (0.72) | PDE4BPDE11APDE10A | |
| SCHEMBL13920547 | 0.69 | PDE4B (0.73) | PDE4BPDE11APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511062-B2 | Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors | SCHERING CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |
| US-7511062-B2 | Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors | SCHERING CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |