Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.64 |
| ▸ | NPC1 | O15118 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | GSK3A | P49840 | 1/20 | 0.56 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.56 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.56 |
| ▸ | SNRK | Q9NRH2 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9093258 | 0.91 | RAB9A (0.69) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL13922829 | 0.89 | RAB9A (0.67) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL17817587 | 0.88 | RAB9A (0.66) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL13922914 | 0.87 | RAB9A (0.59) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL8240613 | 0.87 | RAB9A (0.59) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL8434070 | 0.86 | RAB9A (0.67) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL25131701 | 0.86 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL25131761 | 0.84 | RAB9A (0.58) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL9664553 | 0.84 | RAB9A (0.69) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL22540274 | 0.84 | RAB9A (0.48) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017121649-A1 | 3-(CARBOXYMETHYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES | Grünenthal GmbH (DE) | 2017-07-20 | — | — | WO | disclosed |
| US-7495018-B2 | Substituted 1,3-thiazole compounds, their production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-02-24 | — | — | US | disclosed |