Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bambuterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 1.00 |
| ▸ | BCHE | P06276 | 6/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | ACHE | P22303 | 2/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bambuterol SCHEMBL4431 | 1.00 | BCHE (1.00) | BCHECYP2D6ACHEADRB2KCNH2 | |
| Bambuterol SCHEMBL4432 | 1.00 | BCHE (1.00) | BCHECYP2D6ACHEADRB2KCNH2 | |
| Bambuterol SCHEMBL744580 | 0.99 | BCHE (0.97) | BCHECYP2D6ACHEADRB2KCNH2 | |
| Bambuterol SCHEMBL1649102 | 0.97 | BCHE (0.95) | BCHECYP2D6ACHEADRB2KCNH2 | |
| Bambuterol SCHEMBL3713500 | 0.96 | BCHE (0.92) | BCHECYP2D6ACHEADRB2KCNH2 | |
| SCHEMBL15790253 | 0.95 | BCHE (0.90) | BCHECYP2D6ACHEADRB2KCNH2 | |
| Bambuterol SCHEMBL21645369 | 0.95 | BCHE (0.90) | BCHECYP2D6ACHEADRB2KCNH2 | |
| SCHEMBL21674420 | 0.93 | BCHE (0.88) | BCHECYP2D6ACHEADRB2KCNH2 | |
| Hydrochloric Acid SCHEMBL11123610 | 0.92 | BCHE (0.85) | BCHECYP2D6ACHEADRB2KCNH2 | |
| SCHEMBL15790471 | 0.92 | BCHE (0.85) | BCHECYP2D6ACHEADRB2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115531368-A | Application of R-carbamate-beta-phenylethanolamine compounds in treatment of learning and memory deficiency and neurodegenerative diseases | 谭文 | 2022-12-30 | — | — | CN | claimed |
| WO-2022262873-A2 | APPLICATION OF R-CARBAMATE-β-PHENYLETHANOLAMINE COMPOUND IN TREATMENT OF LEARNING AND MEMORY DEFECTS AND NEURODEGENERATIVE DISEASES | 谭文 | 2022-12-22 | — | — | WO | claimed |
| CN-102448309-A | Use of levorotatory bambuterol for the preparation of an inhaled pharmaceutical formulation and combination for the treatment of respiratory disorders | WEN TAN | 2012-05-09 | — | — | CN | claimed |
| CN-1638756-A | Levo (R) bambuterol and its medicinal use | TAN W (ML) | 2005-07-13 | — | — | CN | claimed |
| CN-113613640-B | New use of R-enantiomer of adrenergic beta 2 receptor agonist for the treatment of inflammatory bowel disease and parenteral diseases | 谭文 | 2024-11-29 | — | — | CN | disclosed |
| CN-113613640-B | New use of R-enantiomer of adrenergic beta 2 receptor agonist for the treatment of inflammatory bowel disease and parenteral diseases | 谭文 | 2024-11-29 | — | — | CN | disclosed |
| CN-118787621-A | New application of R-salbutamol in treating inflammatory bowel disease and extra-intestinal diseases | 谭文 | 2024-10-18 | — | — | CN | disclosed |
| EP-4356912-A2 | HIGH PENETRATION PRODRUG COMPOSITIONS AND PHARMACEUTICAL COMPOSITION THEREOF FOR TREATMENT OF PULMONARY CONDITIONS | Techfields Pharma Co., Ltd. (CN) | 2024-04-24 | — | — | EP | disclosed |
| CN-116077609-B | Yellow thick antidiarrheal quick-release pellet for treating IBD and IBS and preparation method thereof | 安徽雷允上药业有限公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-116077609-A | Yellow thick antidiarrheal quick-release pellet for treating IBD and IBS and preparation method thereof | 安徽雷允上药业有限公司 | 2023-05-09 | — | — | CN | disclosed |
| CN-115531368-A | Application of R-carbamate-beta-phenylethanolamine compounds in treatment of learning and memory deficiency and neurodegenerative diseases | 谭文 | 2022-12-30 | — | — | CN | disclosed |
| CN-115531368-A | Application of R-carbamate-beta-phenylethanolamine compounds in treatment of learning and memory deficiency and neurodegenerative diseases | 谭文 | 2022-12-30 | — | — | CN | disclosed |
| WO-2022262873-A2 | APPLICATION OF R-CARBAMATE-β-PHENYLETHANOLAMINE COMPOUND IN TREATMENT OF LEARNING AND MEMORY DEFECTS AND NEURODEGENERATIVE DISEASES | 谭文 | 2022-12-22 | — | — | WO | disclosed |
| CN-102448309-A | Use of levorotatory bambuterol for the preparation of an inhaled pharmaceutical formulation and combination for the treatment of respiratory disorders | WEN TAN | 2012-05-09 | — | — | CN | disclosed |
| US-7495028-B2 | R-bambuterol, its preparation and therapeutic uses | TAN, WEN, DR. | 2009-02-24 | — | — | US | disclosed |
| CN-100356913-C | Levo (R) bambuterol and its medicinal use | TAN W (CN) | 2007-12-26 | — | — | CN | disclosed |
| CN-1638756-A | Levo (R) bambuterol and its medicinal use | TAN W (ML) | 2005-07-13 | — | — | CN | disclosed |