Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Valproic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.94 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.94 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.94 |
| ▸ | HTR2A | P28223 | 1/20 | 0.94 |
| ▸ | HTR2C | P28335 | 1/20 | 0.94 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.94 |
| ▸ | HRH1 | P35367 | 1/20 | 0.94 |
| ▸ | DRD3 | P35462 | 1/20 | 0.94 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.94 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.94 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.94 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.94 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.60 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.60 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.60 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.60 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valproic Acid SCHEMBL27925984 | 0.97 | CHRM1 (0.89) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL5718019 | 0.97 | CHRM1 (0.89) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL1330837 | 0.97 | CHRM1 (1.00) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL2275 | 0.97 | CHRM1 (1.00) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL140241 | 0.97 | CHRM1 (1.00) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL6910916 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL7579608 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL69795 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL1738242 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL2054191 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 133 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114828841-A | Use of valproic acid for reducing post-operative scarring after glaucoma surgery | 参天制药株式会社 | 2022-07-29 | — | — | CN | claimed |
| WO-2021118469-A1 | USE OF VALPROIC ACID FOR REDUCING POST-OPERATIVE SCARRING FOLLOWING A GLAUCOMA SURGERY | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2021-06-17 | — | — | WO | claimed |
| CN-107811985-B | Anti-epileptic sustained-release preparation and preparation method and application thereof | 四川科瑞德制药股份有限公司 | 2021-05-28 | — | — | CN | claimed |
| WO-2021035655-A1 | MEDICINE FOR INJECTION AND PREPARATION METHOD THEREFOR | 四川科瑞德制药股份有限公司 | 2021-03-04 | — | — | WO | claimed |
| CN-110638801-A | Injection medicine and preparation method thereof | 四川科瑞德制药股份有限公司 | 2020-01-03 | — | — | CN | claimed |
| CN-107811985-A | A kind of anti-epileptic sustained release preparation and preparation method thereof and purposes | 四川科瑞德制药股份有限公司 | 2018-03-20 | — | — | CN | claimed |
| EP-2012794-A2 | COMPOSITIONS AND INTRALUMINAL DEVICES FOR INHIBITING VASCULAR STENOSIS | The Trustees of Columbia University in the City of New York (US) | 2009-01-14 | — | — | EP | claimed |
| WO-2007120897-A2 | COMPOSITIONS AND INTRALUMINAL DEVICES FOR INHIBITING VASCULAR STENOSIS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2007-10-25 | — | — | WO | claimed |
| EP-1267828-B1 | PHARMACEUTICAL PREPARATIONS CONTAINING SACCHAROSE FATTY ACID ESTERS FOR CONTROLLING THE RELEASE OF ACTIVE INGREDIENTS | AWD PHARMA GMBH & CO KG (DE) | 2006-08-02 | — | — | EP | claimed |
| CN-1792364-A | Medicinal composition contg. stavudine and valproic acid or salts thereof | MINGXIN HIGH TECH DEV CO LTD B (CN) | 2006-06-28 | — | — | CN | claimed |
| CN-1212831-C | Pharmaceutical preparations | AWD PHARMA GMBH & CO KG (DE) | 2005-08-03 | — | — | CN | claimed |
| CN-1418091-A | Pharmaceutical preparations | AWD PHARMA GMBH & CO KG (DE) | 2003-05-14 | — | — | CN | claimed |
| US-20020052411-A1 | Valproate compositions and processes for making | AWD.PHARMA GMBH & CO. KG (DE) | 2002-05-02 | — | — | US | claimed |
| US-20020015730-A1 | Pharmaceutical formulations and method for making | AWD.PHARMA GMBH & CO. KG (DE) | 2002-02-07 | — | — | US | claimed |
| US-6287598-B1 | Method for providing sustained antiepileptic therapy | ALZA CORPORATION | 2001-09-11 | — | — | US | claimed |
| US-5980943-A | Sustained antiepileptic therapy | ALZA CORPORATION (US) | 1999-11-09 | — | — | US | claimed |
| US-5707663-A | Sustained antiepileptic therapy | ALZA CORPORATION (US) | 1998-01-13 | — | — | US | claimed |
| WO-1994027587-A2 | SUSTAINED ANTIEPILEPTIC THERAPY | ALZA CORPORATION (US) | 1994-12-08 | — | — | WO | claimed |
| US-4895873-A | ANTIEPILEPSY, ANTICONVULSANT | Desitin Arzenimittel GmbH (DE) | 1990-01-23 | — | — | US | claimed |
| US-4301176-A | CHEWABLE ANTICONVULSANT TABLET | WARNER-LAMBERT COMPANY (US) | 1981-11-17 | — | — | US | claimed |