Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Valproic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.94 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.94 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.94 |
| ▸ | HTR2A | P28223 | 1/20 | 0.94 |
| ▸ | HTR2C | P28335 | 1/20 | 0.94 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.94 |
| ▸ | HRH1 | P35367 | 1/20 | 0.94 |
| ▸ | DRD3 | P35462 | 1/20 | 0.94 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.94 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.94 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.94 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.94 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.60 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.60 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.60 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.60 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valproic Acid SCHEMBL140241 | 0.97 | CHRM1 (1.00) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL2275 | 0.97 | CHRM1 (1.00) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL1330837 | 0.97 | CHRM1 (1.00) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL139238 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL69795 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL6910916 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL7579608 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL2184648 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL1738242 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL21378840 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111329881-A | Oral ulcer film and preparation method and application thereof | 中国医学科学院北京协和医院 | 2020-06-26 | — | — | CN | claimed |
| CN-102326076-B | Chemical indicator compositions, indicators and methods | 3M INNOVATIVE PROPERTIES CO. (US) | 2016-06-01 | — | — | CN | claimed |
| US-9170245-B2 | Chemical indicator composition, indicators and methods | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2015-10-27 | — | — | US | claimed |
| EP-2506006-A1 | Chemical indicator composition, indicators and methods | 3M Innovative Properties Company (US) | 2012-10-03 | — | — | EP | claimed |
| CN-102326076-A | Chemical indicator compositions, indicators and methods | 3M INNOVATIVE PROPERTIES CO | 2012-01-18 | — | — | CN | claimed |
| US-20110275159-A1 | CHEMICAL INDICATOR COMPOSITION, INDICATORS AND METHODS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2011-11-10 | — | — | US | claimed |
| EP-2382461-A2 | CHEMICAL INDICATOR COMPOSITION, INDICATORS AND METHODS | 3M Innovative Properties Company (US) | 2011-11-02 | — | — | EP | claimed |
| WO-2010078422-A2 | CHEMICAL INDICATOR COMPOSITION, INDICATORS AND METHODS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2010-07-08 | — | — | WO | claimed |
| US-20080020059-A1 | COMPOSITIONS AND METHODS FOR TOPICAL TREATMENT OF SKIN INFECTION | CHIOU CONSULTING, INC. (US) | 2008-01-24 | — | — | US | claimed |
| CN-101049316-A | Application of medical use lithium salt or medical use medication of valproic acid class as medication for treating sclerosis of amyotrophia | FENG HONGLIN (CN) | 2007-10-10 | — | — | CN | claimed |
| US-7258875-B2 | Compositions and methods for topical treatment of skin infection | CHIOU CONSULTING, INC. (US) | 2007-08-21 | — | — | US | claimed |
| US-20050186288-A1 | Compositions and methods for the prophylaxis and treatment of aphthous ulcers and herpes simplex lesions | CHIOU CONSULTING INC. (US) | 2005-08-25 | — | — | US | claimed |
| WO-2005055927-A2 | COMPOSITIONS AND METHODS FOR TOPICAL TREATMENT OF SKIN INFECTION | CHIOU CONSULTING INC. (US) | 2005-06-23 | — | — | WO | claimed |
| US-20050123620-A1 | Compositions and methods for topical treatment of skin infection | CHIOU CONSULTING, INC. | 2005-06-09 | — | — | US | claimed |
| US-11484614-B2 | Water-based sterilization indicator composition | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2022-11-01 | — | — | US | disclosed |
| CN-108699374-B | Water-based sterilization indicator composition | 3M创新有限公司 | 2021-07-06 | — | — | CN | disclosed |
| EP-2795312-B1 | WATER-BASED STERILIZATION INDICATOR COMPOSITION, METHOD FOR ITS PREPARATION AND INDICATOR TAPE | 3M INNOVATIVE PROPERTIES CO (US) | 2021-02-24 | — | — | EP | disclosed |
| US-20050123620-A1 | Compositions and methods for topical treatment of skin infection | CHIOU CONSULTING, INC. | 2005-06-09 | — | — | US | disclosed |
| EP-1531837-A1 | COMPOSITIONS AND METHODS FOR THE PROPHYLAXIS AND TREATMENT OF APHTHOUS ULCERS AND HERPES SIMPLEX LESIONS | Chiou Consulting, Inc. (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2003103691-A1 | COMPOSITIONS AND METHODS FOR THE PROPHYLAXIS AND TREATMENT OF APHTHOUS ULCERS AND HERPES SIMPLEX LESIONS | CHIOU CONSULTING, INC. (US) | 2003-12-18 | — | — | WO | disclosed |