Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 19/20 | 0.80 |
| ▸ | GSK3B | P49841 | 19/20 | 0.80 |
| ▸ | CDK1 | P06493 | 18/20 | 0.80 |
| ▸ | CCNB2 | O95067 | 17/20 | 0.80 |
| ▸ | CCNB1 | P14635 | 17/20 | 0.80 |
| ▸ | CCNB3 | Q8WWL7 | 17/20 | 0.80 |
| ▸ | CDK5 | Q00535 | 11/20 | 0.80 |
| ▸ | CDK5R1 | Q15078 | 10/20 | 0.80 |
| ▸ | CDK2 | P24941 | 3/20 | 0.80 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.80 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.80 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.80 |
| ▸ | INSR | P06213 | 1/20 | 0.80 |
| ▸ | CFTR | P13569 | 1/20 | 0.80 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.80 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.80 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.80 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.80 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL490878 | 0.89 | GSK3A (1.00) | GSK3AGSK3BCDK1CCNB2CCNB1 | |
| Aloisine A SCHEMBL80147 | 0.89 | GSK3A (1.00) | GSK3AGSK3BCDK1CCNB2CCNB1 | |
| Aloisine SCHEMBL79714 | 0.87 | GSK3A (1.00) | GSK3AGSK3BCDK1CCNB2CCNB1 | |
| SCHEMBL491260 | 0.82 | GSK3A (1.00) | GSK3AGSK3BCDK1CCNB2CCNB1 | |
| Bromide SCHEMBL490395 | 0.79 | GSK3A (0.97) | GSK3AGSK3BCDK1CCNB2CCNB1 | |
| SCHEMBL6852911 | 0.77 | GSK3A (0.67) | GSK3AGSK3BCDK1CCNB2CCNB1 | |
| SCHEMBL490953 | 0.76 | GSK3A (1.00) | GSK3AGSK3BCDK1CCNB2CCNB1 | |
| SCHEMBL1778992 | 0.75 | GSK3A (0.62) | GSK3AGSK3BCDK1CCNB2CCNB1 | |
| SCHEMBL1778282 | 0.75 | GSK3A (0.58) | GSK3AGSK3BCDK1CCNB2CCNB1 | |
| SCHEMBL1777265 | 0.72 | GSK3A (0.56) | GSK3AGSK3BCDK1CCNB2CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048260-A1 | Use of pyrrolopyrazine derivatives for the production of medicaments for the treatment of mucoviscidosis and diseases related to protein addressing errors in cells | UNIVERSITE DE POITIERS (FR) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048260-A1 | Use of pyrrolopyrazine derivatives for the production of medicaments for the treatment of mucoviscidosis and diseases related to protein addressing errors in cells | HRH2, HRH1, HRH4 | GSK3A 4507/4885GSK3B 4503/4885CDK1 1649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.