Aloisine A

Aloisine A

SCHEMBL80147

CCCCc1c(-c2ccc(O)cc2)[nH]c2nccnc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3A P49840 19/20 1.00
GSK3B P49841 19/20 1.00
CDK1 P06493 18/20 1.00
CCNB2 O95067 17/20 1.00
CCNB1 P14635 17/20 1.00
CCNB3 Q8WWL7 17/20 1.00
CDK5 Q00535 11/20 1.00
CDK5R1 Q15078 10/20 1.00
CDK2 P24941 3/20 1.00
MAPK8 P45983 3/20 1.00
CCNE1 P24864 2/20 1.00
CCNE2 O96020 1/20 1.00
INSR P06213 1/20 1.00
CFTR P13569 1/20 1.00
CCNA2 P20248 1/20 1.00
MAPK3 P27361 1/20 1.00
MAPK1 P28482 1/20 1.00
MAPK9 P45984 1/20 1.00
MAPK10 P53779 1/20 1.00
CCNA1 P78396 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL490395 0.90 GSK3A (0.97) GSK3AGSK3BCDK1CCNB2CCNB1
SCHEMBL13926127 0.89 GSK3A (0.80) GSK3AGSK3BCDK1CCNB2CCNB1
SCHEMBL490878 0.86 GSK3A (1.00) GSK3AGSK3BCDK1CCNB2CCNB1
Aloisine SCHEMBL79714 0.84 GSK3A (1.00) GSK3AGSK3BCDK1CCNB2CCNB1
SCHEMBL27594653 0.82 GSK3A (0.70) GSK3AGSK3BCDK1CCNB2CCNB1
SCHEMBL1778932 0.82 GSK3A (0.69) GSK3AGSK3BCDK1CCNB2CCNB1
SCHEMBL1779346 0.80 GSK3A (0.70) GSK3AGSK3BCDK1CCNB2CCNB1
SCHEMBL1778366 0.80 GSK3A (0.70) GSK3AGSK3BCDK1CCNB2CCNB1
SCHEMBL491260 0.80 GSK3A (1.00) GSK3AGSK3BCDK1CCNB2CCNB1
SCHEMBL7253117 0.80 GSK3A (0.69) GSK3AGSK3BCDK1CCNB2CCNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 692 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260125650-A1 METHODS AND COMPOSITIONS FOR GENERATING HEPATOCYTES TRAILHEAD BIOSYSTEMS INC (US) 2026-05-07 US claimed
US-12564610-B2 Human periventricular endothelial cell therapy for neuropsychiatric disorders THE MCLEAN HOSPITAL CORPORATION (US) 2026-03-03 US claimed
US-20250304916-A1 METHODS AND COMPOSITIONS FOR GENERATING VASCULAR LEPTOMENINGEAL CELLS TRAILHEAD BIOSYSTEMS INC (US) 2025-10-02 US claimed
US-20250108070-A1 METHOD FOR REPROGRAMMING CD8+ T CELLS TO ENHANCE THEIR THERAPEUTIC POTENTIAL AND APPLICATIONS THEREOF INSTITUT PASTEUR (FR) 2025-04-03 US claimed
US-12187698-B2 Crystalline forms of C21H22Cl2N4O2 BIOMED VALLEY DISCOVERIES, INC. (US) 2025-01-07 US claimed
EP-4466342-A1 METHOD FOR REPROGRAMMING CD8+ T CELLS TO ENHANCE THEIR THERAPEUTIC POTENTIAL AND APPLICATIONS THEREOF Institut Pasteur (FR) 2024-11-27 EP claimed
US-11999891-B2 Liquid-crystal medium comprising polymerisable compounds and the use thereof in liquid-crystal displays MERCK PATENT GMBH (DE) 2024-06-04 US claimed
WO-2023139242-A1 METHOD FOR REPROGRAMMING CD8+ T CELLS TO ENHANCE THEIR THERAPEUTIC POTENTIAL AND APPLICATIONS THEREOF INSTITUT PASTEUR (FR) 2023-07-27 WO claimed
US-20220324832-A1 CRYSTALLINE FORMS OF C21H22Cl2N4O2 VERTEX PHARMACEUTICALS INCORPORATED 2022-10-13 US claimed
US-11377596-B2 Liquid-crystalline media MERCK PATENT GMBH (DE) 2022-07-05 US claimed
EP-2346988-B1 DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS TO THE PANCREATIC ENDOCRINE LINEAGE JANSSEN BIOTECH INC (US) 2017-05-31 EP claimed
EP-3523331-B1 CHIMERIC ANTIGEN RECEPTORS FOR THE TREATMENT OF CANCER NOVARTIS AG (CH) 2026-05-27 EP disclosed
EP-3325504-B1 METHODS FOR IMPROVING THE EFFICACY AND EXPANSION OF IMMUNE CELLS NOVARTIS AG (CH) 2026-05-27 EP disclosed
EP-4748905-A1 LIQUID-CRYSTALLINE MEDIUM Merck Patent GmbH (DE) 2026-05-27 EP disclosed
CN-122080952-A Liquid-crystalline medium 2026-05-26 CN disclosed
US-20070078083-A1 MODULATION OF NEUORGENESIS BY HDac INHIBITION BRAINCELLS, INC. (US) 2007-04-05 US disclosed
US-20070049576-A1 NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION BRAINCELLS, INC. (US) 2007-03-01 US disclosed
WO-2007020658-A2 'A NOVEL HOMOLOGY MODEL OF THE GLYCOGEN SYNTHASE KINASE 3 ALPHA AND ITS USES THEREOF' JUBILANT BIOSYS LTD (IN) 2007-02-22 WO disclosed
WO-2006083937-A2 AGENTS AND METHODS RELATED TO REDUCING RESISTANCE TO APOPTOSIS-INDUCING DEATH RECEPTOR AGONISTS THE UAB RESEARCH FOUNDATION (US) 2006-08-10 WO disclosed
EP-1388541-A1 Pyrrolopyrazines as kinase inhibitors CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 2004-02-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220324832-A1 CRYSTALLINE FORMS OF C21H22Cl2N4O2 CYP2F1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CA4 GSK3A 3023/4885GSK3B 2475/4885CDK1 248/4885
US-20250108070-A1 METHOD FOR REPROGRAMMING CD8+ T CELLS TO ENHANCE THEIR THERAPEUTIC POTENTIAL AND APPLICATIONS THEREOF ICOS, CD4, NFATC1 GSK3A 1668/4885GSK3B 1583/4885CDK1 4558/4885
US-20070078083-A1 MODULATION OF NEUORGENESIS BY HDac INHIBITION DCX, BDNF, NTRK2 GSK3A 645/4885GSK3B 629/4885CDK1 635/4885
US-12564610-B2 Human periventricular endothelial cell therapy for neuropsychiatric disorders GABRB3, GABRB1, BMP4 GSK3A 184/4885GSK3B 111/4885CDK1 1965/4885
US-12187698-B2 Crystalline forms of C21H22Cl2N4O2 CYP2F1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CA4 GSK3A 3023/4885GSK3B 2475/4885CDK1 248/4885
US-20070049576-A1 NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION CHRNB2, CHAT, CHRNB4 GSK3A 381/4885GSK3B 337/4885CDK1 485/4885
US-20260125650-A1 METHODS AND COMPOSITIONS FOR GENERATING HEPATOCYTES WNT3A, GSK3B, GSK3A GSK3A 3/4885GSK3B 2/4885CDK1 141/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.