Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.75 |
| ▸ | KDR | P35968 | 18/20 | 0.75 |
| ▸ | MST1R | Q04912 | 3/20 | 0.75 |
| ▸ | AXL | P30530 | 2/20 | 0.75 |
| ▸ | FLT3 | P36888 | 2/20 | 0.75 |
| ▸ | PLK4 | O00444 | 1/20 | 0.75 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.75 |
| ▸ | ABL1 | P00519 | 1/20 | 0.75 |
| ▸ | LCK | P06239 | 1/20 | 0.75 |
| ▸ | FYN | P06241 | 1/20 | 0.75 |
| ▸ | LYN | P07948 | 1/20 | 0.75 |
| ▸ | HCK | P08631 | 1/20 | 0.75 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.75 |
| ▸ | BCR | P11274 | 1/20 | 0.75 |
| ▸ | SRC | P12931 | 1/20 | 0.75 |
| ▸ | ABL2 | P42684 | 1/20 | 0.75 |
| ▸ | FRK | P42685 | 1/20 | 0.75 |
| ▸ | SYK | P43405 | 1/20 | 0.75 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.75 |
| ▸ | MERTK | Q12866 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL104760 | 0.94 | MET (0.78) | METKDRMST1RAXLFLT3 | |
| SCHEMBL2670902 | 0.94 | MET (0.75) | METKDRMST1RAXLFLT3 | |
| Glesatinib SCHEMBL106319 | 0.86 | MET (1.00) | METKDRMST1RAXLFLT3 | |
| Glesatinib SCHEMBL29351360 | 0.86 | MET (1.00) | METKDRMST1RAXLFLT3 | |
| SCHEMBL2670909 | 0.85 | MET (0.70) | METKDRMST1RAXLFLT3 | |
| SCHEMBL104761 | 0.85 | MET (0.69) | METKDRMST1RAXLFLT3 | |
| SCHEMBL13167449 | 0.83 | MET (0.91) | METKDRMST1RAXLFLT3 | |
| SCHEMBL2670515 | 0.82 | MET (0.89) | METKDRMST1RAXLFLT3 | |
| SCHEMBL103919 | 0.82 | MET (0.61) | METKDRMST1RAXLFLT3 | |
| SCHEMBL2673548 | 0.81 | MET (0.91) | METKDRMST1RAXLFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026717-A1 | INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY | METHYLGENE INC. (CA) | 2009-03-05 | — | — | WO | disclosed |