Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5585348 | 0.84 | MEN1 (0.62) | NPC1RAB9AKMT2AMEN1DRD2 | |
| SCHEMBL17993541 | 0.83 | RAB9A (0.49) | NPC1RAB9AKMT2AMEN1DRD2 | |
| SCHEMBL14817515 | 0.79 | MEN1 (0.55) | NPC1RAB9AKMT2AMEN1DRD2 | |
| SCHEMBL2670692 | 0.77 | NPC1 (0.62) | NPC1RAB9AKMT2AMEN1DRD2 | |
| SCHEMBL10202845 | 0.77 | NPC1 (0.62) | NPC1RAB9AKMT2AMEN1DRD2 | |
| SCHEMBL11861565 | 0.77 | KMT2A (0.62) | NPC1RAB9AKMT2AMEN1DRD2 | |
| SCHEMBL610584 | 0.77 | NPC1 (1.00) | NPC1RAB9AKMT2AMEN1DRD2 | |
| SCHEMBL2605827 | 0.75 | MEN1 (0.50) | NPC1RAB9AKMT2AMEN1DRD2 | |
| SCHEMBL10172493 | 0.75 | MEN1 (0.50) | NPC1RAB9AKMT2AMEN1DRD2 | |
| SCHEMBL15014970 | 0.74 | MEN1 (0.49) | NPC1RAB9AKMT2AMEN1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426108-B1 | Processes and intermediates for preparing fused heterocyclic kinase inhibitors | METHYLGENE INC (CA) | 2016-08-10 | — | — | EP | disclosed |
| WO-2009026720-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING FUSED HETEROCYCLIC KINASE INHIBITORS | METHYLGENE INC. (CA) | 2009-03-05 | — | — | WO | disclosed |