Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.60 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.57 |
| ▸ | RBP4 | P02753 | 1/20 | 0.54 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.54 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13930757 | 0.89 | CHRM4 (0.70) | CHRM4TRPA1P2RY12KCNH2TRPM8 | |
| SCHEMBL13930804 | 0.87 | TRPA1 (0.60) | CHRM4TRPA1P2RY12KCNH2TRPM8 | |
| SCHEMBL13377921 | 0.84 | CHRM4 (0.59) | CHRM4TRPA1RBP4P2RY12KCNH2 | |
| SCHEMBL14423759 | 0.84 | P2RY12 (0.59) | CHRM4TRPA1RBP4P2RY12KCNH2 | |
| SCHEMBL13377920 | 0.84 | CHRM4 (0.59) | CHRM4TRPA1RBP4P2RY12KCNH2 | |
| SCHEMBL13377924 | 0.84 | KIT (0.54) | CHRM4RBP4MALT1TRPV1MEN1 | |
| SCHEMBL13377922 | 0.82 | TRPV1 (0.70) | CHRM4TRPA1P2RY12KCNH2TRPM8 | |
| SCHEMBL14423745 | 0.82 | CHRM4 (0.56) | CHRM4TRPA1RBP4P2RY12KCNH2 | |
| SCHEMBL13377919 | 0.78 | CHRM4 (0.54) | CHRM4TRPA1KCNH2TRPM8TRPV1 | |
| SCHEMBL13930750 | 0.77 | TRPA1 (0.63) | CHRM4TRPA1P2RY12KCNH2TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2033951-A2 | 2-Piperazine-pyridines useful for treating pain | EURO-CELTIQUE S.A. (LU) | 2009-03-11 | — | — | EP | disclosed |
| US-7256193-B2 | Therapeutic agents useful for treating pain | EURO-CELTIQUE S.A. (LU) | 2007-08-14 | — | — | US | disclosed |
| US-7256193-B2 | Therapeutic agents useful for treating pain | EURO-CELTIQUE S.A. (LU) | 2007-08-14 | — | — | US | disclosed |