Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 6/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.40 |
| ▸ | KDR | P35968 | 5/20 | 0.40 |
| ▸ | GSK3B | P49841 | 5/20 | 0.39 |
| ▸ | GSK3A | P49840 | 3/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 9/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.37 |
| ▸ | SRC | P12931 | 3/20 | 0.37 |
| ▸ | PAK4 | O96013 | 2/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3532347 | 0.77 | ITK (0.50) | ITKIGF1RFGFR1KDRGSK3B | |
| SCHEMBL3529643 | 0.77 | ITK (0.50) | ITKIGF1RFGFR1KDRGSK3B | |
| SCHEMBL13072363 | 0.77 | ITK (0.50) | ITKIGF1RFGFR1KDRGSK3B | |
| SCHEMBL28521553 | 0.77 | APP (0.40) | — | |
| SCHEMBL20436541 | 0.77 | BACE1 (0.34) | — | |
| SCHEMBL25784063 | 0.76 | POLB (0.39) | — | |
| SCHEMBL11915102 | 0.76 | BACE1 (0.33) | — | |
| SCHEMBL26927340 | 0.75 | GPR84 (0.33) | — | |
| SCHEMBL21264134 | 0.74 | BACE1 (0.33) | — | |
| SCHEMBL20436539 | 0.74 | CACNA1C (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7491720-B2 | Aminopyridine derivatives having Aurora A selective inhibitory action | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-02-17 | — | — | US | disclosed |