Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 7/20 | 0.76 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.76 |
| ▸ | HTR1A | P08908 | 1/20 | 0.76 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.76 |
| ▸ | DRD2 | P14416 | 1/20 | 0.76 |
| ▸ | HTR2A | P28223 | 1/20 | 0.76 |
| ▸ | HTR2C | P28335 | 1/20 | 0.76 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.76 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.76 |
| ▸ | HTR2B | P41595 | 1/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.76 |
| ▸ | PTAFR | P25105 | 8/20 | 0.66 |
| ▸ | SLC6A15 | Q9H2J7 | 5/20 | 0.54 |
| ▸ | FNTA | P49354 | 3/20 | 0.53 |
| ▸ | FNTB | P49356 | 3/20 | 0.53 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azatadine SCHEMBL29363595 | 0.86 | HRH1 (1.00) | HRH1CHRM2HTR1ACHRM1DRD2 | |
| Azatadine SCHEMBL29746602 | 0.86 | HRH1 (1.00) | HRH1CHRM2HTR1ACHRM1DRD2 | |
| Azatadine SCHEMBL3721 | 0.86 | HRH1 (1.00) | HRH1CHRM2HTR1ACHRM1DRD2 | |
| SCHEMBL11925299 | 0.86 | HRH1 (1.00) | HRH1PTAFRSLC6A15FNTAFNTB | |
| Azatadine SCHEMBL6061443 | 0.85 | HRH1 (0.97) | HRH1CHRM2HTR1ACHRM1DRD2 | |
| SCHEMBL9215889 | 0.81 | HRH1 (0.89) | HRH1CHRM2HTR1ACHRM1DRD2 | |
| SCHEMBL8877892 | 0.80 | PTAFR (1.00) | HRH1CHRM2HTR1ACHRM1DRD2 | |
| SCHEMBL9073785 | 0.80 | FNTA (0.76) | HRH1CHRM2HTR1ACHRM1DRD2 | |
| SCHEMBL9073638 | 0.79 | SLC6A15 (0.78) | HRH1CHRM2HTR1ACHRM1DRD2 | |
| Cyproheptadine SCHEMBL5934940 | 0.79 | HRH1 (0.83) | HRH1CHRM2HTR1ACHRM1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482468-B2 | Imidazole and benzimidazole derivatives useful as histamine H3 antagonists | SCHERING CORPORATION (US) | 2009-01-27 | — | — | US | disclosed |