Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12713115 | 0.94 | MAPT (0.48) | MAPTSMN1; SMN2NAMPTGPR119THRB | |
| SCHEMBL12713054 | 0.84 | SSTR1 (0.44) | NAMPTGPR119KDM4EPKMUTS2R | |
| SCHEMBL4675703 | 0.82 | GPR119 (0.51) | MAPTSMN1; SMN2NAMPTGPR119THRB | |
| SCHEMBL11920838 | 0.81 | GPR119 (0.52) | MAPTSMN1; SMN2NAMPTGPR119THRB | |
| SCHEMBL1513166 | 0.80 | GPR119 (0.53) | MAPTSMN1; SMN2NAMPTGPR119THRB | |
| SCHEMBL30233524 | 0.80 | GPR119 (0.53) | MAPTSMN1; SMN2NAMPTGPR119THRB | |
| SCHEMBL12712639 | 0.80 | MAPT (0.48) | MAPTSMN1; SMN2NAMPTGPR119THRB | |
| SCHEMBL11905845 | 0.79 | KDM4E (0.48) | MAPTSMN1; SMN2NAMPTGPR119THRB | |
| SCHEMBL2553555 | 0.78 | GPR119 (0.54) | MAPTSMN1; SMN2NAMPTGPR119THRB | |
| SCHEMBL12712636 | 0.78 | NAMPT (0.49) | MAPTSMN1; SMN2NAMPTGPR119THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009015867-A1 | SUBSTITUTED ARYL OR HETEROARYLPIPERDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2009-02-05 | — | — | WO | disclosed |
| EP-2020405-A1 | Substituted aryl or heteroarylpiperidine derivatives as melanocortin-4 receptor modulators | Santhera Pharmaceuticals (Schweiz) AG (CH) | 2009-02-04 | — | — | EP | disclosed |