Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.58 |
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 1/20 | 0.44 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2198777 | 0.80 | PDGFRB (0.60) | PDGFRBPDGFRABRD4BIRC5TOP2A | |
| SCHEMBL30547072 | 0.80 | PDGFRB (0.60) | PDGFRBPDGFRABRD4BIRC5TOP2A | |
| SCHEMBL1045337 | 0.78 | PDGFRB (0.56) | PDGFRBPDGFRABRD4BIRC5TOP2A | |
| SCHEMBL14784319 | 0.76 | METAP2 (1.00) | METAP2BRD4FLT3AURKAROCK2 | |
| SCHEMBL27833818 | 0.76 | PDGFRB (0.60) | PDGFRBPDGFRABRD4BIRC5TOP2A | |
| SCHEMBL2182815 | 0.76 | PDGFRB (0.60) | PDGFRBPDGFRABRD4BIRC5TOP2A | |
| SCHEMBL29937408 | 0.75 | METAP2 (0.54) | METAP2BRD4PIK3CDHSP90AA1IDO1 | |
| SCHEMBL21514162 | 0.75 | METAP2 (0.66) | METAP2BRD4CREBBPHSP90AA1IDO1 | |
| SCHEMBL17179205 | 0.75 | PIM1 (0.60) | PDGFRBPDGFRABIRC5TOP2ATOP2B | |
| SCHEMBL462907 | 0.74 | PDGFRA (0.51) | PDGFRBPDGFRABRD4BIRC5KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102439003-A | Indazole derivatives inhibiting HSP90, compositions containing said derivatives and uses thereof | SANOFI AVENTIS | 2012-05-02 | — | — | CN | disclosed |
| US-20120010241-A1 | HSP90 INHIBITING INDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME AND USE THEREOF | SANOFI (FR) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010241-A1 | HSP90 INHIBITING INDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME AND USE THEREOF | HSP90AB2P, HSP90AB1, HSP90AA1 | METAP2 4160/4885PDGFRB 1416/4885PDGFRA 1508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.