Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.65 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.60 |
| ▸ | BCDIN3D | Q7Z5W3 | 9/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13944197 | 0.89 | HTR2C (0.61) | HTR2CSHMT2BCDIN3DKMT2AKDM4E | |
| SCHEMBL13943690 | 0.89 | HTR2C (0.69) | HTR2CSHMT2BCDIN3DKMT2AKDM4E | |
| SCHEMBL13942964 | 0.87 | HTR2C (0.67) | HTR2CSHMT2BCDIN3DKMT2AKDM4E | |
| SCHEMBL13942962 | 0.84 | HTR2C (0.82) | HTR2CSHMT2BCDIN3DKMT2AKDM4E | |
| SCHEMBL13943270 | 0.82 | KMT2A (0.61) | HTR2CSHMT2BCDIN3DKMT2AKDM4E | |
| SCHEMBL13943679 | 0.82 | HTR2C (0.69) | HTR2CSHMT2BCDIN3DKMT2AKDM4E | |
| SCHEMBL13943259 | 0.81 | HTR2C (0.74) | HTR2CSHMT2BCDIN3DKMT2AKDM4E | |
| SCHEMBL13943252 | 0.80 | KMT2A (0.64) | HTR2CBCDIN3DKMT2AKDM4EALDH1A1 | |
| SCHEMBL13943727 | 0.79 | HTR2C (1.00) | HTR2CSHMT2BCDIN3DKMT2AKDM4E | |
| SCHEMBL13943729 | 0.78 | HTR2C (0.98) | HTR2CSHMT2BCDIN3DKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023978-A1 | PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE | ONCALIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |