Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.69 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | BCDIN3D | Q7Z5W3 | 10/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13943713 | 0.89 | KMT2A (0.74) | HTR2CSHMT2KDM4EMEN1KMT2A | |
| SCHEMBL13942962 | 0.87 | HTR2C (0.82) | HTR2CSHMT2KDM4EMEN1KMT2A | |
| SCHEMBL13947564 | 0.87 | SHMT2 (0.78) | HTR2CSHMT2BCDIN3DPIK3CA | |
| SCHEMBL13943259 | 0.86 | HTR2C (0.74) | HTR2CSHMT2KDM4EMEN1KMT2A | |
| SCHEMBL13943721 | 0.83 | MEN1 (0.68) | HTR2CSHMT2KDM4EMEN1KMT2A | |
| SCHEMBL13943729 | 0.83 | HTR2C (0.98) | HTR2CSHMT2KDM4EMEN1KMT2A | |
| SCHEMBL13942990 | 0.82 | HTR2C (0.65) | HTR2CSHMT2KDM4EMEN1KMT2A | |
| SCHEMBL13943273 | 0.82 | KDM4E (0.71) | HTR2CSHMT2KDM4EMEN1KMT2A | |
| SCHEMBL13942964 | 0.82 | HTR2C (0.67) | HTR2CSHMT2KDM4EMEN1KMT2A | |
| SCHEMBL13943727 | 0.82 | HTR2C (1.00) | HTR2CSHMT2KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023978-A1 | PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE | ONCALIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | disclosed |