Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 13/20 | 0.59 |
| ▸ | PIM2 | Q9P1W9 | 9/20 | 0.59 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | CYBB | P04839 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL102997 | 0.86 | PIM1 (0.61) | PIM1PIM2FLT3CYBBKDR | |
| SCHEMBL13944547 | 0.83 | PIM1 (0.59) | PIM1PIM2FLT3CYBBKDR | |
| SCHEMBL13501066 | 0.83 | PIM1 (0.65) | PIM1PIM2FLT3MEN1NPC1 | |
| SCHEMBL3563380 | 0.82 | CYBB (0.59) | PIM1PIM2FLT3CYBBKDR | |
| SCHEMBL13500717 | 0.81 | CYBB (0.61) | PIM1PIM2FLT3CYBBSLC2A1 | |
| SCHEMBL8207947 | 0.80 | PIM1 (0.61) | PIM1PIM2FLT3HPGDTGFBR2 | |
| SCHEMBL22421584 | 0.77 | KDR (0.62) | PIM1PIM2KDRHPGDMEN1 | |
| SCHEMBL18362768 | 0.77 | PIM1 (0.78) | PIM1PIM2CYBBSLC2A1HPGD | |
| SCHEMBL13500813 | 0.77 | SLC2A1 (0.70) | PIM1PIM2FLT3CYBBSLC2A1 | |
| SCHEMBL13501227 | 0.77 | CYBB (0.69) | PIM1PIM2FLT3CYBBSLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017954-A1 | INHIBITORS OF JAK2 KINASE | PHENOMIX CORPORATION (US) | 2009-02-05 | — | — | WO | disclosed |