Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.64 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.61 |
| ▸ | BCDIN3D | Q7Z5W3 | 10/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13943721 | 0.87 | MEN1 (0.68) | HTR2CMEN1KMT2AMAPTKDM4E | |
| SCHEMBL13944369 | 0.85 | MEN1 (0.67) | MEN1KMT2AMAPTKDM4EMAPK1 | |
| SCHEMBL13942963 | 0.85 | HTR2C (0.78) | HTR2CMEN1KMT2AMAPTKDM4E | |
| SCHEMBL13947040 | 0.82 | BCDIN3D (0.56) | HTR2CMEN1KMT2AMAPTKDM4E | |
| SCHEMBL13947569 | 0.79 | BCDIN3D (0.55) | MEN1KMT2AMAPTKDM4EMAPK1 | |
| SCHEMBL13944190 | 0.79 | HTR2C (1.00) | HTR2CMEN1KMT2AMAPTKDM4E | |
| SCHEMBL13100664 | 0.78 | KMT2A (1.00) | HTR2CMEN1KMT2AMAPTKDM4E | |
| SCHEMBL13946812 | 0.76 | HTR2C (0.70) | HTR2CMEN1KMT2AMAPTKDM4E | |
| SCHEMBL13947044 | 0.76 | HTR2C (0.70) | HTR2CMEN1KMT2AMAPTKDM4E | |
| SCHEMBL13943273 | 0.76 | KDM4E (0.71) | HTR2CMEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023978-A1 | PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE | ONCALIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |