Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.78 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.73 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.65 |
| ▸ | BCDIN3D | Q7Z5W3 | 10/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13944190 | 0.88 | HTR2C (1.00) | HTR2CSHMT2MAPTKMT2AMEN1 | |
| SCHEMBL13943721 | 0.86 | MEN1 (0.68) | HTR2CSHMT2MAPTTP53KMT2A | |
| SCHEMBL13944354 | 0.85 | HTR2C (0.77) | HTR2CSHMT2MAPTTP53KMT2A | |
| SCHEMBL13944367 | 0.85 | HTR2C (0.65) | HTR2CSHMT2MAPTTP53KMT2A | |
| SCHEMBL13943255 | 0.84 | SHMT2 (0.65) | HTR2CSHMT2MAPTTP53KMT2A | |
| SCHEMBL13943311 | 0.84 | SHMT2 (1.00) | HTR2CSHMT2MAPTKMT2AMEN1 | |
| SCHEMBL3950710 | 0.84 | HTR2C (0.63) | HTR2CSHMT2MAPTTP53KMT2A | |
| SCHEMBL3751015 | 0.83 | MAPT (0.77) | HTR2CSHMT2MAPTTP53KMT2A | |
| SCHEMBL13942983 | 0.82 | SHMT2 (0.78) | HTR2CSHMT2MAPTTP53KMT2A | |
| SCHEMBL13943273 | 0.82 | KDM4E (0.71) | HTR2CSHMT2MAPTTP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023978-A1 | PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE | ONCALIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | disclosed |