Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 4/20 | 0.83 |
| ▸ | HTR2C | P28335 | 4/20 | 0.66 |
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | BCDIN3D | Q7Z5W3 | 8/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SYK | P43405 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13944750 | 0.94 | SHMT2 (0.72) | SHMT2HTR2CBCDIN3DTP53MAPT | |
| SCHEMBL13944348 | 0.91 | SHMT2 (1.00) | SHMT2HTR2CBCDIN3DTP53MAPT | |
| SCHEMBL3753369 | 0.87 | SYK (0.71) | SHMT2HTR2CBCDIN3DTP53MAPT | |
| SCHEMBL12982853 | 0.84 | SHMT2 (0.78) | SHMT2HTR2CBCDIN3DTP53MAPT | |
| SCHEMBL13942961 | 0.84 | SHMT2 (0.71) | SHMT2HTR2CBCDIN3DTP53MAPT | |
| SCHEMBL13943687 | 0.83 | SHMT2 (0.70) | SHMT2BCDIN3DMEN1KMT2ASYK | |
| SCHEMBL3756412 | 0.83 | HTR2C (0.75) | SHMT2HTR2CBCDIN3DTP53MAPT | |
| SCHEMBL17792782 | 0.83 | SHMT2 (0.69) | SHMT2BCDIN3DTP53MAPTMEN1 | |
| SCHEMBL13943694 | 0.82 | SHMT2 (0.68) | SHMT2HTR2CBCDIN3DTP53MAPT | |
| SCHEMBL13942991 | 0.81 | HTR2C (0.63) | SHMT2HTR2CHTR2ABCDIN3DTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023978-A1 | PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE | ONCALIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | disclosed |