Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.51 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | HTR7 | P34969 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | HTR1E | P28566 | 1/20 | 0.46 |
| ▸ | HTR1F | P30939 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13946965 | 0.94 | HTR6 (0.49) | HTR6PPARGPPARDPPARADRD2 | |
| SCHEMBL3036876 | 0.89 | PPARG (0.62) | HTR6PPARGPPARDPPARADRD2 | |
| SCHEMBL15242233 | 0.85 | HTR6 (0.54) | HTR6PPARGPPARDPPARADRD2 | |
| SCHEMBL13947150 | 0.83 | HTR6 (0.52) | HTR6PPARGPPARDPPARADRD2 | |
| SCHEMBL3025310 | 0.83 | PPARG (0.62) | HTR6PPARGPPARDPPARADRD2 | |
| SCHEMBL13947526 | 0.77 | HTR6 (0.76) | HTR6PPARGPPARDPPARADRD2 | |
| SCHEMBL13239839 | 0.76 | HTR6 (0.74) | HTR6PPARGPPARDPPARADRD2 | |
| SCHEMBL13368565 | 0.75 | HTR6 (0.59) | HTR6PPARGPPARDPPARADRD2 | |
| SCHEMBL13239837 | 0.75 | HTR6 (0.67) | HTR6PPARGPPARDPPARADRD2 | |
| SCHEMBL13368596 | 0.75 | HTR6 (0.64) | HTR6PPARGPPARDPPARADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7491831-B2 | PPAR active compounds | PLEXXIKON, INC. (US) | 2009-02-17 | — | — | US | disclosed |
| US-7476746-B2 | PPAR active compounds | PLEXXIKON, INC. (US) | 2009-01-13 | — | — | US | disclosed |