Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 18/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.73 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.73 |
| ▸ | HDAC4 | P56524 | 11/20 | 0.73 |
| ▸ | HDAC7 | Q8WUI4 | 11/20 | 0.73 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.73 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.73 |
| ▸ | HDAC9 | Q9UKV0 | 11/20 | 0.73 |
| ▸ | HDAC5 | Q9UQL6 | 11/20 | 0.73 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 0.73 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.73 |
| ▸ | NAMPT | P43490 | 1/20 | 0.56 |
| ▸ | TET3 | O43151 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.54 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.54 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.54 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.54 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16807371 | 0.84 | HDAC1 (0.73) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL309995 | 0.84 | HDAC1 (1.00) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL309994 | 0.84 | HDAC1 (1.00) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL16806971 | 0.83 | HDAC1 (0.71) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL16806782 | 0.82 | HDAC1 (0.70) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL23054938 | 0.82 | HDAC1 (0.70) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL16806970 | 0.79 | HDAC1 (0.67) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL16806835 | 0.79 | HDAC1 (0.67) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL8242401 | 0.78 | HDAC1 (1.00) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL13949934 | 0.78 | HDAC1 (0.69) | HDAC1HDAC6HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210060014-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | CERENO SCIENTIFIC AB (SE) | 2021-03-04 | — | — | US | disclosed |
| US-20140051716-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | CERENO SCIENTIFIC AB | 2014-02-20 | — | — | US | disclosed |
| US-20090012066-A1 | Method of Use of Deacetylase Inhibitors | NOVARTIS AG | 2009-01-08 | — | — | US | disclosed |
| US-20090012066-A1 | Method of Use of Deacetylase Inhibitors | NOVARTIS AG | 2009-01-08 | — | — | US | disclosed |
| US-20080176849-A1 | DEACETYLASE INHIBITORS | SECURA BIO, INC. | 2008-07-24 | — | — | US | disclosed |
| US-20080176849-A1 | DEACETYLASE INHIBITORS | SECURA BIO, INC. | 2008-07-24 | — | — | US | disclosed |
| EP-1870399-A1 | HYDROXAMATE DERIVATIVES USEFUL AS DEACETYLASE INHIBITORS | Novartis AG (CH) | 2007-12-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140051716-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | HDAC3, HDAC1, HDAC2 | HDAC1 2/4885HDAC6 10/4885HDAC3 1/4885 |
| US-20080176849-A1 | DEACETYLASE INHIBITORS | HDAC1, HDAC3, HDAC6 | HDAC1 1/4885HDAC6 3/4885HDAC3 2/4885 |
| US-20090012066-A1 | Method of Use of Deacetylase Inhibitors | HDAC3, HDAC5, HDAC1 | HDAC1 3/4885HDAC6 10/4885HDAC3 1/4885 |
| US-20210060014-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | HDAC3, HDAC1, HDAC2 | HDAC1 2/4885HDAC6 10/4885HDAC3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.