Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 4/20 | 0.54 |
| ▸ | CDK2 | P24941 | 4/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.54 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.54 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13175411 | 0.89 | CDK9 (0.53) | CDK9CDK2CCNA2CDK5CDK5R1 | |
| SCHEMBL13175630 | 0.89 | CDK9 (0.55) | CDK9CDK2CCNA2CDK5CDK5R1 | |
| SCHEMBL13202868 | 0.87 | CDK9 (0.53) | CDK9CDK2CCNA2CDK5CDK5R1 | |
| SCHEMBL13952907 | 0.85 | CDK2 (0.72) | CDK9CDK2CCNA2CDK5CDK5R1 | |
| SCHEMBL13952910 | 0.83 | CDK9 (0.56) | CDK9CDK2CCNA2CDK5CDK5R1 | |
| SCHEMBL13952912 | 0.81 | CDK9 (0.63) | CDK9CDK2CCNA2CDK5CDK5R1 | |
| SCHEMBL117207 | 0.81 | CDK9 (0.72) | CDK9CDK2CCNA2CDK5CDK5R1 | |
| SCHEMBL13202831 | 0.81 | CDK9 (0.52) | CDK9CDK2CCNA2CDK5CDK5R1 | |
| SCHEMBL13220722 | 0.81 | CDK9 (0.57) | CDK9CDK2CCNA2CDK5CDK5R1 | |
| SCHEMBL14269063 | 0.80 | CDK2 (0.38) | CDK9CDK2CCNA2CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7495000-B2 | Variolin derivatives and their use as antitumor agents | PHARMA MAR, S.A. (ES) | 2009-02-24 | — | — | US | disclosed |