Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 20/20 | 0.83 |
| ▸ | AKR1B1 | P15121 | 9/20 | 0.83 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1406045 | 0.91 | PTGDR2 (1.00) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL1249481 | 0.88 | PTGDR2 (0.79) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL1405972 | 0.88 | PTGDR2 (0.79) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL13952924 | 0.88 | PTGDR2 (0.68) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL1406277 | 0.88 | PTGDR2 (0.79) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL1406364 | 0.86 | PTGDR2 (1.00) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL13952895 | 0.85 | PTGDR2 (0.69) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| Azd1981 SCHEMBL1053662 | 0.85 | PTGDR2 (1.00) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL1251032 | 0.85 | PTGDR2 (0.78) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| Azd1981 SCHEMBL30538014 | 0.85 | PTGDR2 (1.00) | PTGDR2AKR1B1CYP2C9SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2025670-A1 | 3-(Phenyl or quinolyl)thio-1H-indole-1-acetic acid derivatives as modulators of CRTh2 receptor activity | AstraZeneca AB (SE) | 2009-02-18 | — | — | EP | disclosed |