Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 17/20 | 0.68 |
| ▸ | AURKA | O14965 | 11/20 | 0.68 |
| ▸ | LCK | P06239 | 3/20 | 0.48 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.45 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12473154 | 0.89 | AURKB (0.74) | AURKBAURKALCKPTK6CHEK1 | |
| SCHEMBL8241235 | 0.85 | AURKA (0.81) | AURKBAURKACHEK1CDK2 | |
| SCHEMBL14538480 | 0.83 | AURKB (0.49) | AURKBAURKALCKPTK6CHEK1 | |
| SCHEMBL13954940 | 0.82 | AURKB (0.81) | AURKBAURKALCKPTK6CHEK1 | |
| SCHEMBL12473346 | 0.81 | AURKB (1.00) | AURKBAURKALCKPTK6CHEK1 | |
| SCHEMBL8241241 | 0.80 | AURKA (0.90) | AURKBAURKALCKCHEK1CDK2 | |
| SCHEMBL12473048 | 0.79 | LCK (0.74) | AURKBAURKALCKPTK6CHEK1 | |
| SCHEMBL14536797 | 0.77 | AURKB (0.50) | AURKBAURKALCKPTK6CHEK1 | |
| SCHEMBL13155517 | 0.76 | AURKB (0.74) | AURKBAURKALCKPTK6CHEK1 | |
| SCHEMBL14534093 | 0.76 | AURKA (0.53) | AURKBAURKACHEK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017701-A2 | ANTI-MITOTIC AGENT AND AURORA KINASE INHIBITOR COMBINATION AS ANTI-CANCER TREATMENT | SCHERING CORPORATION (US) | 2009-02-05 | — | — | WO | disclosed |