Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 10/20 | 0.50 |
| ▸ | AURKA | O14965 | 5/20 | 0.50 |
| ▸ | PTK6 | Q13882 | 7/20 | 0.44 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 5/20 | 0.37 |
| ▸ | FLT3 | P36888 | 3/20 | 0.36 |
| ▸ | NRAS | P01111 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14538480 | 0.95 | AURKB (0.49) | AURKBAURKAPTK6MAPKAPK5LCK | |
| SCHEMBL14507668 | 0.85 | AURKB (0.65) | AURKBAURKAPTK6MAPKAPK5FLT3 | |
| SCHEMBL8241222 | 0.80 | AURKA (0.58) | AURKBAURKACHEK1CDK2 | |
| SCHEMBL12473154 | 0.78 | AURKB (0.74) | AURKBAURKAPTK6LCKCHEK1 | |
| SCHEMBL13954832 | 0.77 | AURKB (0.68) | AURKBAURKAPTK6LCKCHEK1 | |
| SCHEMBL13954946 | 0.73 | PTK6 (0.53) | AURKBAURKAPTK6MAPKAPK5LCK | |
| SCHEMBL13954945 | 0.73 | PTK6 (0.53) | AURKBAURKAPTK6MAPKAPK5LCK | |
| SCHEMBL12473053 | 0.72 | AURKB (0.54) | AURKBAURKAPTK6MAPKAPK5LCK | |
| SCHEMBL14530391 | 0.71 | AURKB (0.51) | AURKBAURKAPTK6MAPKAPK5LCK | |
| SCHEMBL14536960 | 0.69 | MAPKAPK5 (0.62) | AURKBAURKAPTK6MAPKAPK5LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058942-A2 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |