Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 11/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | PTK6 | Q13882 | 12/20 | 0.46 |
| ▸ | LCK | P06239 | 8/20 | 0.42 |
| ▸ | NRAS | P01111 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13954863 | 0.88 | CHEK1 (0.45) | AURKBAURKACHEK1IRAK4 | |
| SCHEMBL14507770 | 0.80 | AURKB (0.62) | AURKBAURKAPTK6LCKCHEK1 | |
| SCHEMBL13954940 | 0.79 | AURKB (0.81) | AURKBAURKAPTK6LCKCHEK1 | |
| SCHEMBL13954917 | 0.77 | AURKB (0.60) | AURKBAURKAPTK6LCKCHEK1 | |
| SCHEMBL13954920 | 0.77 | LCK (0.47) | AURKBAURKAPTK6LCKCHEK1 | |
| SCHEMBL13954903 | 0.75 | AURKB (0.56) | AURKBAURKAPTK6LCKCHEK1 | |
| SCHEMBL14346920 | 0.69 | AURKB (0.45) | AURKBAURKAPTK6LCKNRAS | |
| SCHEMBL13954832 | 0.68 | AURKB (0.68) | AURKBAURKAPTK6LCKCHEK1 | |
| SCHEMBL13954830 | 0.68 | AURKB (0.47) | AURKBAURKAPTK6LCKFLT3 | |
| SCHEMBL14507450 | 0.67 | AURKB (1.00) | AURKBAURKAPTK6LCKCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017701-A2 | ANTI-MITOTIC AGENT AND AURORA KINASE INHIBITOR COMBINATION AS ANTI-CANCER TREATMENT | SCHERING CORPORATION (US) | 2009-02-05 | — | — | WO | disclosed |