Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.34 |
| ▸ | KIT | P10721 | 3/20 | 0.34 |
| ▸ | FLT1 | P17948 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7205123 | 0.85 | FLT1 (0.44) | KDRSMN1; SMN2PDGFRBKITFLT1 | |
| SCHEMBL1383073 | 0.76 | CCNK (0.35) | KDRGAASMN1; SMN2PDGFRBKIT | |
| SCHEMBL1383890 | 0.75 | GAA (0.37) | KDRGAAMAPT | |
| SCHEMBL1383433 | 0.74 | NAMPT (0.47) | KDRFLT1MAPTCYP1A2 | |
| SCHEMBL1384331 | 0.73 | NAMPT (0.36) | KDRGAASMN1; SMN2PDGFRBKIT | |
| SCHEMBL13955578 | 0.73 | KDR (0.54) | KDRPDGFRBKITFLT1MAPT | |
| SCHEMBL13955450 | 0.73 | FLT1 (0.48) | KDRSMN1; SMN2PDGFRBKITFLT1 | |
| SCHEMBL13955594 | 0.72 | KDR (0.51) | KDRPDGFRBKITFLT1 | |
| SCHEMBL13955639 | 0.70 | SMN1; SMN2 (0.52) | KDRGAASMN1; SMN2PDGFRBKIT | |
| SCHEMBL13955448 | 0.69 | FLT1 (0.47) | KDRGAASMN1; SMN2PDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603566-B1 | USE OF ISOQUINOLINE DERIVATIVES FOR TREATING CANCER AND MAP KINASE RELATED DISEASES | NOVARTIS AG (CH) | 2009-01-21 | — | — | EP | disclosed |