Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.44 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 9/20 | 0.44 |
| ▸ | FLT1 | P17948 | 8/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.44 |
| ▸ | KIT | P10721 | 6/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | HLA-A | P04439 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13955585 | 0.87 | KDR (0.55) | SMN1; SMN2MAPTNPC1RAB9AKMT2A | |
| SCHEMBL13955571 | 0.85 | KDR (0.48) | SMN1; SMN2MAPTNPC1RAB9AKDR | |
| SCHEMBL13955411 | 0.82 | KDR (0.48) | MAPTRAB9AKDRFLT1PDGFRB | |
| SCHEMBL13955487 | 0.82 | RAB9A (0.46) | SMN1; SMN2NPC1RAB9AKMT2AKDR | |
| SCHEMBL2201541 | 0.81 | FLT1 (0.64) | KDRFLT1PDGFRBKITCIT | |
| SCHEMBL13955486 | 0.81 | FLT1 (0.64) | SMN1; SMN2MAPTNPC1RAB9AKMT2A | |
| SCHEMBL13955592 | 0.81 | CYP1A2 (0.46) | SMN1; SMN2MAPTKMT2ANAMPTKDR | |
| SCHEMBL3668971 | 0.81 | KDR (0.66) | SMN1; SMN2KDRFLT1PDGFRBKIT | |
| SCHEMBL7205123 | 0.81 | FLT1 (0.44) | SMN1; SMN2NAMPTKDRFLT1PDGFRB | |
| SCHEMBL13955485 | 0.79 | FLT1 (0.52) | RAB9AKMT2ANAMPTKDRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603566-B1 | USE OF ISOQUINOLINE DERIVATIVES FOR TREATING CANCER AND MAP KINASE RELATED DISEASES | NOVARTIS AG (CH) | 2009-01-21 | — | — | EP | disclosed |