Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 8/20 | 0.56 |
| ▸ | BCR | P11274 | 8/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CTSC | P53634 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 4/20 | 0.44 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.42 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13955414 | 0.86 | PLK1 (0.46) | ABL1BCREPHX2RAB9AFLT1 | |
| SCHEMBL1382926 | 0.84 | FLT1 (0.46) | FLT1KDRCYP3A4 | |
| SCHEMBL1382851 | 0.82 | FLT1 (0.60) | FLT1KDR | |
| SCHEMBL1386339 | 0.82 | KDR (0.48) | NPC1RAB9AFLT1KDR | |
| SCHEMBL1383504 | 0.81 | KDR (0.44) | FLT1KDRCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1386811 | 0.81 | KDR (0.44) | CTSCFLT1KDR | |
| SCHEMBL1387032 | 0.80 | KDR (0.54) | FLT1KDR | |
| SCHEMBL1383042 | 0.79 | KIF11 (0.53) | CTSCFLT1KDRDHODHCYP3A4 | |
| SCHEMBL1385235 | 0.77 | NAMPT (0.46) | NPC1CTSCFLT1KDR | |
| SCHEMBL1383724 | 0.77 | KDR (0.53) | CTSCFLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603566-B1 | USE OF ISOQUINOLINE DERIVATIVES FOR TREATING CANCER AND MAP KINASE RELATED DISEASES | NOVARTIS AG (CH) | 2009-01-21 | — | — | EP | disclosed |