Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 10/20 | 0.58 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | BCL2 | P10415 | 1/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | BAD | Q92934 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13955581 | 0.87 | HTR1B (0.58) | HTR1BNR2E1KMT2AKDM4EALDH1A1 | |
| SCHEMBL13955536 | 0.80 | NR2E1 (0.58) | HTR1BNR2E1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7279604 | 0.76 | HTR1B (0.65) | HTR1BNR2E1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6849540 | 0.75 | HTR1B (0.63) | HTR1BKDM4EALDH1A1HPGDMCL1 | |
| SCHEMBL15501176 | 0.74 | HTR1B (1.00) | HTR1BNR2E1KMT2AKDM4EALDH1A1 | |
| SCHEMBL10922354 | 0.74 | HTR1B (0.59) | HTR1BNR2E1KMT2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL11338197 | 0.73 | HTR1B (0.57) | HTR1BNR2E1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2925774 | 0.73 | HTR1B (0.62) | HTR1BNR2E1KDM4EALDH1A1HPGD | |
| SCHEMBL2177350 | 0.72 | HTR1B (0.78) | HTR1BNR2E1KMT2AHTR1DSLC6A4 | |
| SCHEMBL9770352 | 0.72 | KCNA3 (0.81) | HTR1BNR2E1KMT2AHTR1DSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542687-B1 | SMALL ORGANIC MOLECULES THAT INCREASE THE ACTIVITY OF GELATINASE A IN OCULAR CELLS | BAUSCH & LOMB (US) | 2009-01-28 | — | — | EP | disclosed |