Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL611282 | 0.91 | CYP2D6 (0.55) | ACHECYP2D6KCNH2 | |
| SCHEMBL2207909 | 0.87 | CYP2D6 (0.56) | ACHECYP2D6KCNH2 | |
| SCHEMBL29818840 | 0.87 | CYP2D6 (0.56) | ACHECYP2D6KCNH2 | |
| SCHEMBL2205020 | 0.85 | PDK2 (0.49) | CYP2D6KCNH2 | |
| SCHEMBL29818912 | 0.85 | PDK2 (0.49) | CYP2D6KCNH2 | |
| SCHEMBL3179388 | 0.83 | FFAR1 (0.48) | ACHECYP2D6KCNH2FFAR1F10 | |
| SCHEMBL23771271 | 0.82 | CYP2D6 (0.71) | CYP2D6FFAR1 | |
| SCHEMBL13959276 | 0.81 | FFAR1 (0.51) | ACHECYP2D6FFAR1 | |
| SCHEMBL7557832 | 0.80 | CYP2D6 (0.57) | ACHECYP2D6KCNH2 | |
| SCHEMBL4568886 | 0.80 | CYP2D6 (0.67) | CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130030026-A1 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA INC. (US) | 2013-01-31 | — | — | US | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130030026-A1 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | PDE6D, STARD3, PDE6C | ACHE 3354/4885CYP2D6 3791/4885KCNH2 2318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.