SCHEMBL1395992

SCHEMBL1395992

O=CCc1ncc(F)cc1F

nearest known ligand 0.40

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
AGBL2 Q5U5Z8 1/20 0.40
MAPK1 P28482 1/20 0.31
ERN1 O75460 1/20 0.31
ADORA2A P29274 1/20 0.30
TNKS O95271 1/20 0.30
PARP1 P09874 1/20 0.30
TNKS2 Q9H2K2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17224965 0.81 HTT (0.31)
SCHEMBL4673064 0.76 AGBL2 (0.37) AGBL2
SCHEMBL2172358 0.76 AGBL2 (0.37) AGBL2
SCHEMBL14738285 0.76 AGBL2 (0.37) AGBL2MAPK1ADORA2A
SCHEMBL23695333 0.72 AGBL2 (0.39) AGBL2
SCHEMBL9951955 0.72 AGBL2 (0.39) AGBL2
SCHEMBL29475252 0.72 AGBL2 (0.39) AGBL2
SCHEMBL134813 0.72 AGBL2 (0.43) AGBL2MAPK1ADORA2A
SCHEMBL29941432 0.72 AGBL2 (0.43) AGBL2MAPK1ADORA2A
SCHEMBL357848 0.72 AGBL2 (0.39) AGBL2ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4514794-A1 FGFR2 INHIBITOR COMPOUNDS Eli Lilly and Company (US) 2025-03-05 EP disclosed
WO-2023212535-A1 FGFR2 INHIBITOR COMPOUNDS ELI LILLY AND COMPANY (US) 2023-11-02 WO disclosed
EP-3983073-A1 SUBSTITUTED PYRAZOLO[4,3-B]PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS Janssen Pharmaceutica NV (BE) 2022-04-20 EP disclosed
WO-2020249791-A1 SUBSTITUTED PYRAZOLO[4,3-b]PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2020-12-17 WO disclosed
EP-2346859-A1 HETEROCYCLIC JAK KINASE INHIBITORS AstraZeneca AB (SE) 2011-07-27 EP disclosed
EP-2288602-A1 TRICYCLIC 2,4-DIAMIN0-L,3,5-TRIAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF CANCER AND MYELOPROLIFERATIVE DISORDERS AstraZeneca AB (SE) 2011-03-02 EP disclosed
WO-2010038060-A1 HETEROCYCLIC JAK KINASE INHIBITORS ASTRAZENECA AB (SE) 2010-04-08 WO disclosed
WO-2010020810-A1 2-(IMIDAZ0LYLAMIN0)-PYRIDINE DERIVATIVES AND THEIR USE AS JAK KINASE INHIBITORS ASTRAZENECA AB (SE) 2010-02-25 WO disclosed
WO-2009150462-A1 TRICYCLIC 2,4-DIAMIN0-L,3,5-TRIAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF CANCER AND MYELOPROLIFERATIVE DISORDERS ASTRAZENECA AB (SE) 2009-12-17 WO disclosed
WO-2009016410-A2 CHEMICAL COMPOUNDS 831 ASTRAZENECA AB (SE) 2009-02-05 WO disclosed
WO-2008132502-A1 PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER ASTRAZENECA AB (SE) 2008-11-06 WO disclosed