Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.34 |
| ▸ | BCR | P11274 | 4/20 | 0.34 |
| ▸ | BRAF | P15056 | 11/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.32 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13960481 | 0.87 | BRAF (0.40) | ABL1BRAF | |
| SCHEMBL13960017 | 0.87 | BRAF (0.38) | ABL1BCRBRAFEGFRHTR2A | |
| SCHEMBL12465106 | 0.84 | ABL1 (0.48) | ABL1BCRBRAF | |
| SCHEMBL17612910 | 0.79 | BRAF (0.40) | BRAF | |
| SCHEMBL12398402 | 0.78 | ABL1 (0.49) | ABL1BCRBRAF | |
| SCHEMBL13960524 | 0.77 | BRAF (0.42) | ABL1BCRBRAFDDR1DDR2 | |
| SCHEMBL12398650 | 0.77 | ABL1 (0.42) | ABL1BCRTEKFLT1KDR | |
| SCHEMBL17612903 | 0.77 | BRAF (0.34) | BRAFEGFRHTR2AFLT1KDR | |
| SCHEMBL13960499 | 0.77 | BRAF (0.48) | ABL1BCRBRAFEGFRDDR1 | |
| SCHEMBL13960483 | 0.77 | BTK (0.43) | ABL1BCRBRAFDDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009003999-A2 | CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-01-08 | — | — | WO | disclosed |