Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 8/20 | 0.44 |
| ▸ | DRD4 | P21917 | 8/20 | 0.44 |
| ▸ | DRD3 | P35462 | 8/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4477912 | 0.82 | MEN1 (0.63) | MEN1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14202129 | 0.81 | MEN1 (0.56) | MEN1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL13960709 | 0.80 | DRD2 (0.50) | POLBDRD2DRD4DRD3ADRB2 | |
| SCHEMBL4477967 | 0.80 | MEN1 (0.53) | MEN1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4468502 | 0.76 | POLB (0.60) | MEN1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL30905277 | 0.74 | POLB (0.82) | MEN1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4476360 | 0.73 | MEN1 (0.73) | MEN1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9186295 | 0.69 | MEN1 (0.77) | MEN1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL31651583 | 0.68 | DRD2 (0.84) | DRD2DRD4DRD3ADRB2CHRM2 | |
| SCHEMBL26117575 | 0.68 | DRD2 (0.84) | DRD2DRD4DRD3ADRB2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476675-B2 | Quinolinone derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2009-01-13 | — | — | US | disclosed |