Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARK3 | P27448 | 18/20 | 0.70 |
| ▸ | ULK1 | O75385 | 2/20 | 0.55 |
| ▸ | ULK2 | Q8IYT8 | 2/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.55 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.55 |
| ▸ | SGK1 | O00141 | 2/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.53 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | RAF1 | P04049 | 2/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.53 |
| ▸ | LCK | P06239 | 2/20 | 0.53 |
| ▸ | CSF1R | P07333 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3766796 | 0.89 | MARK3 (0.88) | MARK3ULK1ULK2MKNK2STK17A | |
| SCHEMBL13961208 | 0.82 | MARK3 (0.59) | MARK3ULK1ULK2MKNK2STK17A | |
| SCHEMBL3754830 | 0.73 | MARK3 (0.71) | MARK3ULK1ULK2MKNK2STK17A | |
| SCHEMBL3767768 | 0.72 | MARK3 (0.88) | MARK3ULK1ULK2MKNK2STK17A | |
| SCHEMBL3768925 | 0.71 | MARK3 (0.77) | MARK3ULK1ULK2MKNK2STK17A | |
| SCHEMBL3769003 | 0.71 | MARK3 (0.73) | MARK3ULK1ULK2MKNK2STK17A | |
| SCHEMBL3762989 | 0.71 | MARK3 (0.72) | MARK3ULK1ULK2MKNK2STK17A | |
| SCHEMBL3762982 | 0.71 | MARK3 (1.00) | MARK3ULK1ULK2MKNK2STK17A | |
| SCHEMBL25395801 | 0.71 | ULK1 (1.00) | MARK3ULK1ULK2MKNK2STK17A | |
| SCHEMBL3759865 | 0.71 | MARK3 (0.71) | MARK3ULK1ULK2MKNK2STK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009014620-A1 | PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES | MERCK & CO., INC. (US) | 2009-01-29 | — | — | WO | disclosed |