Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.45 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.42 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.41 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13961733 | 0.88 | CHRM5 (0.47) | SLC5A1SLC5A2HTTTSHRCHRM5 | |
| SCHEMBL13961589 | 0.85 | TSHR (0.44) | TSHRCHRM5CHRM1CHRM3BRD4 | |
| SCHEMBL30336383 | 0.83 | SLC5A1 (0.52) | RORCATAD2SLC5A1SLC5A2HTT | |
| SCHEMBL16601596 | 0.83 | TSHR (0.55) | RORCSLC5A1SLC5A2HTTTSHR | |
| SCHEMBL20116324 | 0.83 | SLC5A1 (0.52) | RORCATAD2SLC5A1SLC5A2HTT | |
| SCHEMBL13960954 | 0.82 | CHRM5 (0.42) | HTTTSHRCHRM5CHRM1CHRM3 | |
| SCHEMBL8127407 | 0.82 | ATAD2 (0.56) | RORCATAD2SLC5A1SLC5A2HTT | |
| SCHEMBL9275467 | 0.82 | CHRM5 (0.57) | RORCSLC5A1SLC5A2HTTTSHR | |
| SCHEMBL13961977 | 0.81 | CHRM5 (0.41) | SLC5A1SLC5A2HTTTSHRCHRM5 | |
| Hydrochloric Acid SCHEMBL20703948 | 0.81 | ATAD2 (0.55) | RORCATAD2SLC5A1SLC5A2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009012421-A1 | CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-01-22 | — | — | WO | disclosed |