ATAD2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1158647	0.52	5/20
SCHEMBL866250	0.50	5/20
SCHEMBL1158435	0.52	4/20
SCHEMBL1709906	0.43	4/20
SCHEMBL274672	0.38	4/20
SCHEMBL82566	0.55	3/20
SCHEMBL82901	0.54	3/20
Hydrochloric Acid (SCHEMBL70439)	0.53	3/20
Hydrochloric Acid (SCHEMBL68445)	0.52	3/20
SCHEMBL639918	0.50	3/20
SCHEMBL639919	0.50	3/20
SCHEMBL1158534	0.41	3/20
SCHEMBL1158606	0.40	3/20
SCHEMBL1158890	0.40	3/20
SCHEMBL1059858	0.40	3/20
SCHEMBL865048	0.39	3/20
SCHEMBL714484	1.00	2/20
Thymine (SCHEMBL535796)	0.70	2/20
SCHEMBL653811	0.64	2/20
SCHEMBL1196275	0.61	2/20

Clinical trials — most relevant to ATAD2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
PhII 5-Azacytidine Plus Valproic Acid and Eventually Atra in Intermediate II and High Risk MDS	PHASE2	COMPLETED
Trial of the Histone-Deacetylase Inhibitor ITF2357 Followed by Mechlorethamine in Relapsed/Refractory Hodgkin's Lymphoma	PHASE1/PHASE2	COMPLETED
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)	PHASE1/PHASE2	RECRUITING
Evaluation of the Safety and the Tolerability of a Combination of Two HIV Inducers in Patients With Undetectable Viral Load	PHASE1	COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Genetic Basis of Abdominal Aortic Aneurysm	nan	COMPLETED
Identification of Genes and Pathogenesis Involved in Familial Thoracic Aortic Aneurysm	nan	COMPLETED
Pathogenetic Basis of Aortopathy and Aortic Valve Disease	nan	ACTIVE_NOT_RECRUITING
Epigenomic Profiling of Circulating Cell-Free DNA (cfDNA) to Characterize the Dynamic Evolution of Molecular Subtypes in Extensive-Stage Small Cell Lung Cancer During First-Line Chemoimmunotherapy	nan	NOT_YET_RECRUITING
Familial Intracranial Aneurysm Study II	nan	COMPLETED
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Amyotrophic Lateral Sclerosis (ALS) Families Project	nan	RECRUITING
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Quantitative Assessment of the Etiologies of Megalencephaly Associated With a Detectable Tumor Risk	nan	NOT_YET_RECRUITING
Core Stability Exercises and Hereditary Ataxia	nan	COMPLETED
Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics	nan	UNKNOWN
Identification of a New Gene Involved in Hereditary Lipodystrophy	nan	COMPLETED
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models	nan	COMPLETED
Mapping Novel Disease Genes for Dilated Cardiomyopathy	nan	COMPLETED
Phenotypic and Genotypic Studies in Congenital and Early Onset Ataxias	nan	COMPLETED
PCD New Gene Discovery	nan	COMPLETED
Delineating the Molecular Spectrum and the Clinical, Imaging and Neuronal Phenotype of Chopra-Amiel-Gordon Syndrome	nan	RECRUITING
Genetic and Functional Analysis of Aplasia Cutis Congenital (ACC)	nan	RECRUITING
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders	nan	COMPLETED
Muscle Tissue Bank for Muscular Dystrophy	nan	COMPLETED
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve	nan	UNKNOWN
Genetics and Psychopathology in the 22q11 Deletion Syndrome	nan	UNKNOWN
Hereditary Nonpolyposis Colorectal Cancer in Taiwan-Related Genetic Study and Clinical Applications	nan	UNKNOWN
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ATAD2 binder may also engage these)

Protein	Name	Similarity
P40340	—	1.000	P40340 →
O14114	—	0.998	O14114 →
Q9NRR4	—	0.997	Q9NRR4 →
Q8CDM1	—	0.997	Q8CDM1 →
Q8BMD7	—	0.997	Q8BMD7 →
A4IHT0	—	0.997	A4IHT0 →
C5DX31	—	0.997	C5DX31 →
A8X0L9	—	0.997	A8X0L9 →
Q9W1R5	—	0.997	Q9W1R5 →
Q08BS4	—	0.996	Q08BS4 →
BRPF3	Bromodomain and PHD finger-containing protein 3	0.996	landscape →
X5LX76	—	0.996	X5LX76 →
KATNAL2	Katanin p60 ATPase-containing subunit A-like 2	0.996	landscape →
P54816	—	0.996	P54816 →
Q60575	—	0.995	Q60575 →
Q66624	—	0.995	Q66624 →
Q9USQ1	—	0.995	Q9USQ1 →
G5EEC5	—	0.995	G5EEC5 →
G5EEM9	—	0.995	G5EEM9 →
Q5RDX4	—	0.995	Q5RDX4 →
Q9VFG8	—	0.995	Q9VFG8 →
Q5VW22	—	0.995	Q5VW22 →
Q9H329	—	0.995	Q9H329 →
G5EEW9	—	0.995	G5EEW9 →
Q13415	—	0.995	Q13415 →
Q6FTT0	—	0.995	Q6FTT0 →
B3M301	—	0.995	B3M301 →
Q5FWR0	—	0.995	Q5FWR0 →
Q80WL2	—	0.995	Q80WL2 →
Q7PLI7	—	0.995	Q7PLI7 →