Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.31 |
| ▸ | WNT3A | P56704 | 1/20 | 0.31 |
| ▸ | CETP | P11597 | 1/20 | 0.30 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13273130 | 0.86 | CTNNB1 (0.41) | KIF11CTNNB1WNT3ANOTUMPIK3CA | |
| SCHEMBL31461389 | 0.86 | CTNNB1 (0.41) | KIF11CTNNB1WNT3ANOTUMPIK3CA | |
| SCHEMBL16127115 | 0.77 | TSHR (0.56) | KIF11NPC1RAB9A | |
| SCHEMBL397438 | 0.73 | MAPT (0.55) | KIF11CTNNB1WNT3ANOTUMPIK3CA | |
| SCHEMBL993766 | 0.73 | KIF11 (0.40) | KIF11CTNNB1WNT3ANOTUMPIK3CA | |
| SCHEMBL6208612 | 0.73 | KIF11 (0.40) | KIF11CTNNB1WNT3ANOTUMPIK3CA | |
| SCHEMBL6442096 | 0.73 | AHR (0.50) | KIF11 | |
| SCHEMBL1765169 | 0.73 | CYP3A4 (0.45) | KIF11CTNNB1WNT3A | |
| SCHEMBL423132 | 0.73 | KIF11 (0.40) | KIF11 | |
| SCHEMBL316417 | 0.73 | AHR (0.50) | KIF11CTNNB1WNT3ANOTUMPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009012421-A1 | CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-01-22 | — | — | WO | disclosed |