Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30615684 | 0.82 | NPC1 (0.58) | NPC1HPGDTSHRMAPK1 | |
| SCHEMBL13367759 | 0.82 | MIF (0.58) | MIF | |
| SCHEMBL28500980 | 0.82 | NPC1 (0.58) | NPC1HPGDTSHRMAPK1 | |
| SCHEMBL13341017 | 0.79 | PPARG (0.46) | MIF | |
| SCHEMBL30195005 | 0.78 | TSHR (0.64) | MIFUSP2HPGDTSHRMAPK1 | |
| SCHEMBL16948413 | 0.75 | MIF (0.59) | MIFNPC1TSHR | |
| SCHEMBL16932267 | 0.75 | CBX7 (0.49) | NPC1 | |
| SCHEMBL30214700 | 0.75 | CBX7 (0.49) | NPC1 | |
| SCHEMBL21992180 | 0.72 | MIF (0.56) | MIF | |
| SCHEMBL17766397 | 0.72 | KMO (0.41) | MIFKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009012421-A1 | CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-01-22 | — | — | WO | disclosed |