Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | PPME1 | Q9Y570 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9109048 | 0.70 | TRIM24 (0.50) | TRIM24TRIM33ATMALDH1A1GAA | |
| SCHEMBL5797252 | 0.64 | CRBN (0.41) | TRIM24TRIM33ATMALDH1A1GAA | |
| SCHEMBL28845024 | 0.64 | TRIM24 (0.44) | TRIM24TRIM33ATMALDH1A1S1PR4 | |
| SCHEMBL6653561 | 0.63 | TRIM24 (0.39) | TRIM24TRIM33ATMALDH1A1S1PR4 | |
| SCHEMBL4127228 | 0.63 | AR (0.42) | TRIM24TRIM33 | |
| SCHEMBL28900913 | 0.62 | TRIM24 (0.41) | TRIM24TRIM33ATMALDH1A1CYP11B1 | |
| SCHEMBL31145945 | 0.62 | TRIM24 (0.50) | TRIM24TRIM33ATMALDH1A1S1PR4 | |
| SCHEMBL6650788 | 0.60 | TRIM24 (0.61) | TRIM24TRIM33ATMALDH1A1S1PR4 | |
| SCHEMBL1703803 | 0.60 | — | — | |
| SCHEMBL3934072 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2288611-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen Inc. (US) | 2011-03-02 | — | — | EP | disclosed |
| WO-2009117157-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2009-09-24 | — | — | WO | disclosed |