Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | FABP4 | P15090 | 1/20 | 0.31 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.31 |
| ▸ | MPO | P05164 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4039739 | 0.85 | GCGR (0.51) | GCGRALDH1A1 | |
| SCHEMBL13963393 | 0.78 | ADORA1 (0.54) | GCGRADORA1TP53MAPTLMNA | |
| SCHEMBL4084784 | 0.70 | ADORA1 (0.61) | ADORA1MAPTLMNAALDH1A1HPGD | |
| SCHEMBL27418736 | 0.70 | MAPT (0.51) | ADORA1MAPTLMNAALDH1A1HPGD | |
| SCHEMBL4040868 | 0.69 | GCGR (0.48) | GCGRALDH1A1 | |
| SCHEMBL27418748 | 0.69 | KDM4E (0.46) | ADORA1MAPTALDH1A1HPGD | |
| SCHEMBL14408979 | 0.68 | MAPT (0.43) | ADORA1MAPTNR1H2ALDH1A1HPGD | |
| SCHEMBL13963391 | 0.68 | GCGR (0.38) | GCGRTP53MAPTTHRBLMNA | |
| SCHEMBL27418742 | 0.67 | ALDH1A1 (0.46) | TP53MAPTTHRBLMNAALDH1A1 | |
| SCHEMBL17933981 | 0.67 | SCN4A (0.45) | ADORA1GCKMAPTMPOKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549655-B1 | SUBSTITUTED BICYCLIC THIOPHENE DERIVATIVES, COMPOSTIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 2009-01-21 | — | — | EP | disclosed |