Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ibuprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 0.68 |
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.68 |
| ▸ | CXCR1 | P25024 | 5/20 | 0.68 |
| ▸ | CXCR2 | P25025 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.68 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.68 |
| ▸ | ALB | P02768 | 1/20 | 0.68 |
| ▸ | ESR1 | P03372 | 1/20 | 0.68 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.68 |
| ▸ | RARB | P10826 | 1/20 | 0.68 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.68 |
| ▸ | HTR2A | P28223 | 1/20 | 0.68 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.68 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.68 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.68 |
| ▸ | BLM | P54132 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ibuprofen SCHEMBL8081018 | 1.00 | CXCR1 (0.68) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL17373646 | 1.00 | CXCR1 (0.68) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL997451 | 1.00 | CXCR1 (0.68) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL8076351 | 0.98 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL139269 | 0.98 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL5971384 | 0.94 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL9321827 | 0.94 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL30222251 | 0.94 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL465258 | 0.94 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL1179006 | 0.94 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 232 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4732210-A1 | ENVIRONMENTAL ATTRIBUTES FOR ACTIVE PHARMACEUTICAL INGREDIENTS AND/OR INTERMEDIATES THEREOF | BASF SE (DE) | 2026-04-29 | — | — | EP | claimed |
| US-20250064764-A1 | AQUEOUS FORMULATION COMPRISING PARACETAMOL AND IBUPROFEN | Hyloris Pharmaceuticals SA (BE) | 2025-02-27 | — | — | US | claimed |
| WO-2024260988-A1 | ENVIRONMENTAL ATTRIBUTES FOR ACTIVE PHARMACEUTICAL INGREDIENTS AND/OR INTERMEDIATES THEREOF | BASF SE (DE) | 2024-12-26 | — | — | WO | claimed |
| EP-4482082-A1 | ENVIRONMENTAL ATTRIBUTES FOR ACTIVE PHARMACEUTICAL INGREDIENTS AND/OR INTERMEDIATES THEREOF | BASF SE (DE) | 2024-12-25 | — | — | EP | claimed |
| EP-3174527-B1 | DOSAGE FORM OF SODIUM IBUPROFEN DIHYDRATE ON MESOPOROUS SILICA | JOHNSON & JOHNSON CONSUMER INC (US) | 2021-02-17 | — | — | EP | claimed |
| CN-104922084-B | Sodium ibuprofen tablet and method for preparing pharmaceutical composition containing sodium ibuprofen | 惠氏有限责任公司 | 2020-01-14 | — | — | CN | claimed |
| US-10391072-B2 | High content sodium ibuprofen granules, their preparation and their use in preparing non-effervescent solid dosage forms | SI GROUP, INC. (US) | 2019-08-27 | — | — | US | claimed |
| EP-2965746-B1 | An oral pharmaceutical composition comprising ibuprofen, ibuprofen sodium dihydrate, pseudoephedrine hydrochloride and chlorpheniramine maleate | SANTA FARMA ILAC SANAYI A S (TR) | 2019-03-13 | — | — | EP | claimed |
| CN-104884048-B | High-content Sodium ibuprofen particle, its preparation and its preparing the purposes in non-effervescent solid dosage forms | SI集团有限公司 | 2018-11-23 | — | — | CN | claimed |
| WO-2018053423-A1 | PHARMACEUTICAL COMPOSITION OF IBUPROFEN SODIUM FOR ORAL ADMINISTRATION | Innovazone Labs LLC (US) | 2018-03-22 | — | — | WO | claimed |
| US-20110182984-A1 | High Content Sodium Ibuprofen Granules, Their Preparation And Their Use In Preparing Non-Effervescent Solid Dosage Forms | ALBEMARLE CORPORATION (US) | 2011-07-28 | — | — | US | claimed |
| US-20110140298-A1 | METHOD AND APPARATUS OR DRY GRANULATION | ATACAMA LABS OY (FI) | 2011-06-16 | — | — | US | claimed |
| CN-102099017-A | High content sodium ibuprofen granules, their preparation and their use in preparing non-effervescent solid dosage forms | ALBEMARLE CORP | 2011-06-15 | — | — | CN | claimed |
| EP-2309988-A1 | HIGH CONTENT SODIUM IBUPROFEN GRANULES, THEIR PREPARATION AND THEIR USE IN PREPARING NON-EFFERVESCENT SOLID DOSAGE FORMS | Albemarle Corporation (US) | 2011-04-20 | — | — | EP | claimed |
| WO-2010011522-A1 | HIGH CONTENT SODIUM IBUPROFEN GRANULES, THEIR PREPARATION AND THEIR USE IN PREPARING NON-EFFERVESCENT SOLID DOSAGE FORMS | ALBEMARLE CORPORATION (US) | 2010-01-28 | — | — | WO | claimed |
| WO-2009135949-A2 | PROCESS FOR PREPARING A VERY HIGH DRUG LOAD TABLET | ATACAMA LABS OY (FI) | 2009-11-12 | — | — | WO | claimed |
| WO-2009101258-A1 | NOVEL PHARMACEUTICAL FORMULATION | ATACAMA LABS OY (FI) | 2009-08-20 | — | — | WO | claimed |
| US-20060286164-A1 | Pharmaceutical composition containing a stable and clear solution of anti-inflammatory drug in soft gelatin capsule and process for producing the same | STRIDES ARCOLAB LIMITED (IN) | 2006-12-21 | — | — | US | claimed |
| WO-2005120459-A2 | PHARMACEUTICAL COMPOSITION CONTAINING A STABLE AND CLEAR SOLUTION OF ANTI-INFLAMMATORY DRUG IN SOFT GELATIN CAPSULE AND PROCESS FOR PRODUCING THE SAME | STRIDES ARCOLAB LIMITED (IN) | 2005-12-22 | — | — | WO | claimed |
| CN-1068305-C | Therapeutic agent | BOOTS CO PLC (GB) | 2001-07-11 | — | — | CN | claimed |