Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ibuprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 0.68 |
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.68 |
| ▸ | CXCR1 | P25024 | 5/20 | 0.68 |
| ▸ | CXCR2 | P25025 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.68 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.68 |
| ▸ | ALB | P02768 | 1/20 | 0.68 |
| ▸ | ESR1 | P03372 | 1/20 | 0.68 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.68 |
| ▸ | RARB | P10826 | 1/20 | 0.68 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.68 |
| ▸ | HTR2A | P28223 | 1/20 | 0.68 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.68 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.68 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.68 |
| ▸ | BLM | P54132 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ibuprofen SCHEMBL8081018 | 1.00 | CXCR1 (0.68) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL17373646 | 1.00 | CXCR1 (0.68) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL139713 | 1.00 | CXCR1 (0.68) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL8076351 | 0.98 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL139269 | 0.98 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL5971384 | 0.94 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL9321827 | 0.94 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL30222251 | 0.94 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL465258 | 0.94 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL1179006 | 0.94 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445486-A2 | SODIUM IBUPROFEN TABLETS AND METHODS OF MANUFACTURING PHARMACEUTICAL COMPOSITIONS INCLUDING SODIUM IBUPROFEN | Wyeth LLC (US) | 2012-05-02 | — | — | EP | claimed |
| WO-2011005478-A2 | SODIUM IBUPROFEN TABLETS AND METHODS OF MANUFACTURING PHARMACEUTICAL COMPOSITIONS INCLUDING SODIUM IBUPROFEN | WYETH LLC (US) | 2011-01-13 | — | — | WO | claimed |
| US-20100323005-A1 | Sodium Ibuprofen Tablets and Methods of Manufacturing Pharmaceutical Compositions Including Sodium Ibuprofen | WYETH LLC (US) | 2010-12-23 | — | — | US | claimed |
| CN-100592909-C | Dosage form of sodium ibuprofen | BAYER CONSUMER CARE AG | 2010-03-03 | — | — | CN | claimed |
| US-20080020042-A1 | Dosage form of sodium ibuprofen | RHOA INDUSTRIES, AN INDIAN PARTNERSHIP FIRM (IN) | 2008-01-24 | — | — | US | claimed |
| CN-1705470-A | Dosage form of sodium ibuprofen | BAYER CONSUMER CARE AG (CH) | 2005-12-07 | — | — | CN | claimed |
| EP-1410793-B1 | Delivery form of sodium ibuprofen | BAYER CONSUMER CARE AG (CH) | 2005-11-16 | — | — | EP | claimed |
| US-20040102522-A1 | Dosage form of sodium ibuprofen | BAYER CONSUMER CARE AG (CH) | 2004-05-27 | — | — | US | claimed |
| WO-2004035024-A1 | DOSAGE FORM OF SODIUM IBUPROFEN | BAYER CONSUMER CARE AG (CH) | 2004-04-29 | — | — | WO | claimed |
| CN-104922084-B | Sodium ibuprofen tablet and method for preparing pharmaceutical composition containing sodium ibuprofen | 惠氏有限责任公司 | 2020-01-14 | — | — | CN | disclosed |
| EP-2291233-B1 | METHOD FOR DRY GRANULATION | ATACAMA LABS OY (FI) | 2019-09-04 | — | — | EP | disclosed |
| US-10391072-B2 | High content sodium ibuprofen granules, their preparation and their use in preparing non-effervescent solid dosage forms | SI GROUP, INC. (US) | 2019-08-27 | — | — | US | disclosed |
| US-10265272-B2 | Method and apparatus for dry granulation | ATACAMA LABS OY (FI) | 2019-04-23 | — | — | US | disclosed |
| CN-104884048-B | High-content Sodium ibuprofen particle, its preparation and its preparing the purposes in non-effervescent solid dosage forms | SI集团有限公司 | 2018-11-23 | — | — | CN | disclosed |
| CN-1705470-A | Dosage form of sodium ibuprofen | BAYER CONSUMER CARE AG (CH) | 2005-12-07 | — | — | CN | disclosed |
| CN-1705470-A | Dosage form of sodium ibuprofen | BAYER CONSUMER CARE AG (CH) | 2005-12-07 | — | — | CN | disclosed |
| US-20040102522-A1 | Dosage form of sodium ibuprofen | BAYER CONSUMER CARE AG (CH) | 2004-05-27 | — | — | US | disclosed |
| US-20040102522-A1 | Dosage form of sodium ibuprofen | BAYER CONSUMER CARE AG (CH) | 2004-05-27 | — | — | US | disclosed |
| WO-2004035024-A1 | DOSAGE FORM OF SODIUM IBUPROFEN | BAYER CONSUMER CARE AG (CH) | 2004-04-29 | — | — | WO | disclosed |
| WO-2004035024-A1 | DOSAGE FORM OF SODIUM IBUPROFEN | BAYER CONSUMER CARE AG (CH) | 2004-04-29 | — | — | WO | disclosed |